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---
license: mit
configs:
- config_name: dataset
data_files: "dataset.csv"
---
### Description
This dataset contains ΔΔG value of various protein mutations (including some human designed proteins). The ΔΔG value indicates the stability of protein.
**Protein Format:** AA sequence
### Splits
traing: 486352
valid: 60995
test: 60492
### Related paper
Tsuboyama, K., Dauparas, J., Chen, J. et al. Mega-scale experimental analysis of protein folding stability in biology and design. Nature 620, 434–444 (2023).
https://doi.org/10.1038/s41586-023-06328-6.
### Label
Label means ΔΔG of each mutant amino acid sequence based on a deep mutation scanning experiment.
#### Understanding ΔG (delta G)
ΔG is the Gibbs free energy change of a process, dictating whether a process is thermodynamically favorable:
Negative ΔG: Indicates the process is energetically favorable. For protein unfolding, it implies the protein is more stable in its unfolded form.
Positive ΔG: Indicates the process is not energetically favorable. In protein unfolding, it means the protein requires energy to maintain its unfolded state, i.e. it is stable in folded form.
#### The delta delta G (ΔΔG) represents the deltaG of the mutation compared to the base protein:
Positive ΔΔG: Suggests the mutation enhances protein stability.
Negative ΔΔG: Suggests the mutation decreases protein stability. |