---
license: mit
tags:
- biology
---
### Description
This dataset contains ΔΔG value of various protein mutations (including some human designed proteins). The ΔΔG value indicates the stability of protein.

### Splits
traing: 486352

valid: 60995

test: 60492

### Related paper 
Tsuboyama, K., Dauparas, J., Chen, J. et al. Mega-scale experimental analysis of protein folding stability in biology and design. Nature 620, 434–444 (2023).
https://doi.org/10.1038/s41586-023-06328-6.

### Label
Label means ΔΔG of each mutant amino acid sequence based on a deep mutation scanning experiment.

#### Understanding ΔG (delta G)
ΔG is the Gibbs free energy change of a process, dictating whether a process is thermodynamically favorable:

Negative ΔG: Indicates the process is energetically favorable. For protein unfolding, it implies the protein is more stable in its unfolded form.

Positive ΔG: Indicates the process is not energetically favorable. In protein unfolding, it means the protein requires energy to maintain its unfolded state, i.e. it is stable in folded form.

#### The delta delta G (ΔΔG) represents the deltaG of the mutation compared to the base protein:

Positive ΔΔG: Suggests the mutation enhances protein stability.

Negative ΔΔG: Suggests the mutation decreases protein stability.