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0 | Clinical features of culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia | OBJECTIVE: This retrospective chart review describes the epidemiology and clinical features of 40 patients with culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. METHODS: Patients with positive M. pneumoniae cultures from respiratory specimens from January 1997... | Mycoplasma pneumoniae is a common cause of upper and lower respiratory tract infections. It remains one of the most frequent causes of atypical pneumonia particu-larly among young adults. [1, 2, 3, 4, 5] Although it is highly transmissible, most infections caused by this organism are relatively minor and include pharyn... |
1 | Nitric oxide: a pro-inflammatory mediator in lung disease? | Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO•) and increased indices of NO• -dependent oxidative stress. Although NO• is known to have anti-microbial, anti-inflammatory and anti-oxidant properties, various lines of evidence support the contribution ... | Since its discovery as a biological messenger molecule more than 10 years ago, the gaseous molecule nitric oxide (NO • ) is now well recognized for its involvement in diverse biological processes, including vasodilation, bronchodilation, neurotransmission, tumor surveillance, antimicrobial defense and regulation of inf... |
2 | Surfactant protein-D and pulmonary host defense | Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and secreted by alveolar and bronchiolar epithelial cells, but is also expressed by epithelial cells lining various e... | Surfactant protein-D (SP-D) is a member of the collagenous subfamily of calcium-dependent lectins (collectins) that includes pulmonary surfactant protein A (SP-A) and the serum mannose-binding lectin [1] [2] [3] . Collectins inter-act with a wide variety of microorganisms, lipids, and organic particulate antigens, and ... |
3 | Role of endothelin-1 in lung disease | Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, b... | from Xenopus laevis [16] . ETA receptors in normal lung are found in greatest abundance on vascular and airway smooth muscle, whereas ETB receptors are most often found on the endothelium. Clearance of ET-1 from the circulation is mediated by the ETB receptor primarily in the lung, but also in the kidney and liver [17]... |
4 | Gene expression in epithelial cells in response to pneumovirus infection | Respiratory syncytial virus (RSV) and pneumonia virus of mice (PVM) are viruses of the family Paramyxoviridae, subfamily pneumovirus, which cause clinically important respiratory infections in humans and rodents, respectively. The respiratory epithelial target cells respond to viral infection with specific alterations ... | RSV and PVM are viruses of the family Paramyxoviridae, subfamily pneumovirus; they are enveloped, singlestranded, nonsegmented RNA viruses that can cause intense viral bronchiolitis in humans and mice, respectively. In its most severe form, the lower respiratory tract infection caused by pneumoviruses is associated wit... |
5 | Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis | Nidovirus subgenomic mRNAs contain a leader sequence derived from the 5′ end of the genome fused to different sequences (‘bodies’) derived from the 3′ end. Their generation involves a unique mechanism of discontinuous subgenomic RNA synthesis that resembles copy-choice RNA recombination. During this process, the nascen... | The genetic information of RNA viruses is organized very ef®ciently. Practically every nucleotide of their genome is utilized, either as protein-coding sequence or as cis-acting signals for translation, RNA synthesis or RNA encapsidation. As part of their genome expression strategy, several groups of positive-strand RN... |
6 | Debate: Transfusing to normal haemoglobin levels will not improve outcome | "Recent evidence suggests that critically ill patients are able to tolerate lower levels of haemoglo(...TRUNCATED) | "Anaemia is a common condition in critically ill patients, and RBC transfusions are often used in th(...TRUNCATED) |
7 | "The 21st International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium, 20-23(...TRUNCATED) | "The 21st International Symposium on Intensive Care and Emergency Medicine was dominated by the resu(...TRUNCATED) | "This year's symposium was dominated by the results of recent clinical trials. After 10 years of 'ma(...TRUNCATED) |
8 | Heme oxygenase-1 and carbon monoxide in pulmonary medicine | "Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection against oxidative stre(...TRUNCATED) | "The heme oxygenase-1/carbon monoxide (HO-1/CO) system has recently seen an explosion of research in(...TRUNCATED) |
9 | Technical Description of RODS: A Real-time Public Health Surveillance System | "This report describes the design and implementation of the Real-time Outbreak and Disease Surveilla(...TRUNCATED) | "Unfortunately, conventional public health disease surveillance-which relies on physician and labora(...TRUNCATED) |
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