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22
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19.1
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593
d1a05a_d1dgsa3:d1a05a_-d1dgsa3
d1a05a_d1dgsa3
malisam
d1a05a_d1dgsa3:d1a05a_
d1a05a_d1dgsa3:d1dgsa3
PPAKRPEQGLLRLRKGLDLYANLRPAQIFDVDILVVRELTGNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGS
FTYEEVLAFEERLEREAEAPSLYTVEHKVDFPVEHCYEKALGAEGVEEVYRRGLAQRHALPFEADGVVLKLDDLTLWGELGYTARAPRFALAYKFP
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1.538462
[]
{"notes": "In 1a05, motif occurs at the interface of the two duplicates.\nIn 1dgs, the motif is a circularly permuted reverse-ferredoxin core.\n", "source_file": "d1a05a_d1dgsa3.manual.ali"}
d1a05a_d1j71a_:d1a05a_-d1j71a_
d1a05a_d1j71a_
malisam
d1a05a_d1j71a_:d1a05a_
d1a05a_d1j71a_:d1j71a_
LYANLRPAQIFDVDILVVRELTGGNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGSA
SVELRVHLGSINFDGTSVSTNADVVLDSGTTITYFSQSTADKFARIVGATWDSRNEIYRLPSCDLSGDAVFNFDQGVKITVPLSELILKDSDSSICYFGISRNDANILGDNFLRRAYIVYDLDDKTISLAQVKYTSSSDISAL
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4.444444
[]
{"notes": "The motif in 1a05: motif occurs at the interface of the two duplicates.\nThe motif in 1j71: a core motif. Alternatively, this can be regarded as an interface motif because it uses corresponding elements from the two duplicates.\n", "source_file": "d1a05a_d1j71a_.manual.ali"}
d1a05a_d1rblm_:d1a05a_-d1rblm_
d1a05a_d1rblm_
malisam
d1a05a_d1rblm_:d1a05a_
d1a05a_d1rblm_:d1rblm_
PPAKRPEQGLLRLRKGLDLYANLRPAQIFDVDILVVRELTGGNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGSA
SMKTLPKERRFETFSYLPPLSDRQIAAQIEYMIEQGFHPLIEFNEHSNPEEFYWTMWKLPLFACAAPQQVLDEVRECRSEYGDCYIRVAGFDNIKECQTSSFIVHRPGR
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8.695652
[]
{"notes": "The motif in 1a05: motif occurs at the interface of the two duplicates. circularly permuted reverse-ferredoxin.\n", "source_file": "d1a05a_d1rblm_.manual.ali"}
d1a2za_d1ghha_:d1a2za_-d1ghha_
d1a2za_d1ghha_
malisam
d1a2za_d1ghha_:d1a2za_
d1a2za_d1ghha_:d1ghha_
YSNITVERATLPVRAITKTLRDNGIPATISYSAYPLKAGFIHVPYTPDQVVNKFFLLGKNTPSMCLEAEIKAIELAVKVSLDYLEKDRDDIKIPL
MRIEVTIAKTSPLPAGAIDALAGELSRRIQYAFPDNEGHVSVRYAAANNLSVIGATKEDKQRISEILQETWESADDWFVSE
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16.071429
[]
{"notes": "d1a2za_ hits d1nc3a_ (other superfamily) with Dali Z 13.3, and d2pth__ (othersuperfamily) hits d1nc3a_ with Z 9.5, thus d1a2za_ and d2pth__\nare homologs (the Z score between these two is 7.6, less than 9). In addition, the superposition of 1a2z and 2pth has some details suggesting\nhomology between them. Compare d1a2za_ and d2pth__, one strand and one helix in the motif are insertions. So this is a hybrid motif.\n", "source_file": "d1a2za_d1ghha_.manual.ali"}
d1a2za_d1u9da_:d1a2za_-d1u9da_
d1a2za_d1u9da_
malisam
d1a2za_d1u9da_:d1a2za_
d1a2za_d1u9da_:d1u9da_
SNITVERATLPVRAITKTLRDNGIPATISYSAYPLKAGFIHVPYTPDQVVNKFFLLGKNTPSMCLEAEIKAIELAVKVSLDYLEKDRDDIKIPLKPEIVINLGLAPTY
MPHLRFRAVEAHIVESLVPTLLNELSSLLSTARNAFTFELINTQYFAEGGVYPMVEVLWFGREQQTQDQIAQVITDQIRQLLGADSHLAVVFIPLQRTAYYLDGQHF
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5.882353
[]
{"notes": "d1a2za_ hits d1nc3a_ (other superfamily) with Dali Z 13.3, and d2pth__ (othersuperfamily) hits d1nc3a_ with Z 9.5, thus d1a2za_ and d2pth__\nare homologs (the Z score between these two is 7.6, less than 9). In addition, the superposition of 1a2z and 2pth has some details suggesting\nhomology between them. Compare d1a2za_ and d2pth__, one strand and one helix in the motif are insertions. So this is a hybrid motif.\n", "source_file": "d1a2za_d1u9da_.manual.ali"}
d1a7j__d1kafa_:d1a7j__-d1kafa_
d1a7j__d1kafa_
malisam
d1a7j__d1kafa_:d1a7j__
d1a7j__d1kafa_:d1kafa_
DINFQRVPVVDTSNPFIARWIPTADESVVVIRFRNPRGIDFPYLTSMIHGSWMSRANSIVVPGNKLDLAMQLILTPL
MEITSDMEEDKDLMLKLLDKNGFVLKKVEIYRSNYLAILEKRTNGIRNFEINNNGNMRIFGYKMMEHHIQKFTDIGMSCKIAKNGNVYLDIKRSAENIEAVITVASEL
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11.111111
[]
{"notes": "The motif in 1a7j: comparing d1a7j__ and 1uj2 (same SCOP family), three strands and one helix in the motif in 1a7j are absent in 1uj2. So\nthis is a hybrid motif.\n", "source_file": "d1a7j__d1kafa_.manual.ali"}
d1a7j__d2if1__:d1a7j__-d2if1__
d1a7j__d2if1__
malisam
d1a7j__d2if1__:d1a7j__
d1a7j__d2if1__:d2if1__
DINFQRVPVVDTSNPFIARWIPTADESVVVIRFRNPRGIDFPYLTSMIHGSWMSRANSIVVPGNKLDLAMQLILTPL
MRGSHHHHHHTDPMSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLVEIGLAKDDQLKVHGF
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10.169492
[]
{"notes": "The motif in 1a7j: comparing d1a7j__ and 1uj2 (same SCOP family), three strands and one helix in the motif in 1a7j are absent in 1uj2. So\nthis is a hybrid motif.\n", "source_file": "d1a7j__d2if1__.manual.ali"}
d1aa7a_d1b68a_:d1aa7a_-d1b68a_
d1aa7a_d1b68a_
malisam
d1aa7a_d1b68a_:d1aa7a_
d1aa7a_d1b68a_:d1b68a_
ILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQ
GQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY
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11.666667
[]
{"notes": "The motif in 1aa7 uses helices from the two different domains and the linker helix, and is an interface motif.\nAlthough the first domain in 1aa7_A is also a 4-helix up-and-down bundle, this bundle cannot be homologous to the 4-helix\nbundle in 1b68, because they are mirror images, i.e. superimpose helix 1 and 2 in 1b68 and 1aa7, helix 3 and 4 are on\ndifferent sides of the plane formed by helix 1 and 2.\n", "source_file": "d1aa7a_d1b68a_.manual.ali"}
d1aa7a_d1qkra_:d1aa7a_-d1qkra_
d1aa7a_d1qkra_
malisam
d1aa7a_d1qkra_:d1aa7a_
d1aa7a_d1qkra_:d1qkra_
MSLLTEVETYVLSIIPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQ
KDEEFPEQKAGEAINQPMMMAARQLHDEARKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGNKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRK
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4
[]
{"notes": "The motif in 1aa7 uses helices from the two different domains and the linker helix, and is an interface motif.\nAlthough the first domain in 1aa7_A is also a 4-helix up-and-down bundle, this bundle cannot be homologous to the 4-helix bundle in 1qkr,\nbecause they are mirror images.\nNote that in 1qkr paper, the authors mentioned that \"five-helix bundles are uncommon,..\" in page 606.\n", "source_file": "d1aa7a_d1qkra_.manual.ali"}
d1ac5__d1jroa3:d1ac5__-d1jroa3
d1ac5__d1jroa3
malisam
d1ac5__d1jroa3:d1ac5__
d1ac5__d1jroa3:d1jroa3
SDDAVSFDWIHKSKSTDDSEEFSGYVKYDRNLTFVSVYNASHMVPFDKSLVSRGIVDIYSNDVMIIDNNGKNVMITT
PGLRCYKLSKRFDQDISAVCGCLNLTLKGSKIETARIAFGGMAGVPKRAAAFEAALIGQDFREDTIAAALPLLAQDFTPLSDMRASAAYRMNAAQAMALRYVRELSGEAVAVLEVMP
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0
[]
{"notes": "The motif in 1ac5: four strands are insertions to the Rossmann core, while one strand and the helix belong to the Rossmann core. Hybrid\nmotif, but the b-a-b connection in this motif is left-handed.\n", "source_file": "d1ac5__d1jroa3.manual.ali"}
d1ac5__d1vk0a_:d1ac5__-d1vk0a_
d1ac5__d1vk0a_
malisam
d1ac5__d1vk0a_:d1ac5__
d1ac5__d1vk0a_:d1vk0a_
IEIVLFNGDKDLICNNKGVLDTIDNLKWGGIKGFSDDAVSFDWIHKSKSTDDSEEFSGYVKYDRNLTFVSVYNA
SASFDGPKFKMTDGSYVQTKTIDVGSSTDISPYLSLIREDSILNGNRAVIFDVYWDVGFTKTSGWSLSSVKLSTRNLCLFLRLPKPFHDNLKDLYRFFASKFVTFVGVQIEEDLDLLRENHGLVIRNAINVGKLAAEARGTLVLEFLGTRELAHRVLWSDLGQLDSIEAKWEKAGPEEQLEAAAIEGWLIVNVWDQLSDE
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10.909091
[]
{"notes": "The motif in 1ac5: 2nd and 3rd helices are insertion, other elements belong to the Rossmann core. hybrid motif;\nThe motif in 1vk0: 1st strand and 1st helix are insertion, other elements belong to the RNaseH core. hybrid motif;\nBasically, insertion in RNaseH is aligned to core elements in Rossmann, and insertion in Rossmann is aligned to core elements in RNaseH.\n", "source_file": "d1ac5__d1vk0a_.manual.ali"}
d1adja2d1drw_2:d1adja2-d1drw_2
d1adja2d1drw_2
malisam
d1adja2d1drw_2:d1adja2
d1adja2d1drw_2:d1drw_2
SENPILDAEAVVLLYECLKELGLRRLKVKLSSVGLGEEARAHLKEVERHLERLSVPYELEPALVRGLDYYVRTAFEVHHEEIGAQSALGGGGRYD
VGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKDCAVYSREGHTGERVPGTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSR
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1.408451
[]
{"notes": "The motif in 1adj: comparing d1adja2 and d1bia_3 (different family same superfamily), the helix and the second strand are insertion. hybrid. the\ninserted beta-strand is short.\n", "source_file": "d1adja2d1drw_2.manual.ali"}
d1aora2d1dkza2:d1aora2-d1dkza2
d1aora2d1dkza2
malisam
d1aora2d1dkza2:d1aora2
d1aora2d1dkza2:d1dkza2
SPENKLIIAAGPLTGTSAPTGGRYNVVTKSPLTGFITMANSGGYSEKVKIASIGPAGENLVKFAAIMNDGHRAAGRGG
VLLLDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFSTAEDNQSAVSIHVLQGERKRAADNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSG
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4.918033
[]
{"notes": "The motif in 1aor: interface motif involving the two duplicates; crossed connection;\n", "source_file": "d1aora2d1dkza2.manual.ali"}
d1axn__d1nkta3:d1axn__-d1nkta3
d1axn__d1nkta3
malisam
d1axn__d1nkta3:d1axn__
d1axn__d1nkta3:d1nkta3
LSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNDEFTLNRIMVSRSEID
ILSKLLRLGEGRMVKRLKKVADYVGTLSDDVEKLTDAELRAKTDEFKRRLADQKNPETLDDLLPEAFAVAREAAWRVLDQRP
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6.818182
[]
{"notes": "The motif in 1axn: the 3-helix bundle uses helix 5 in the 1st duplicate, helix 1 in the 2nd duplicate, and helix 2 in the 5th duplicate.\nThis is an interface motif at the interface of three duplicates and in any one duplicate, the arrangement of helix\n1,2,5 is different than the arrangement in the interface motif.\n", "source_file": "d1axn__d1nkta3.manual.ali"}
d1axn__d1sf9a_:d1axn__-d1sf9a_
d1axn__d1sf9a_
malisam
d1axn__d1sf9a_:d1axn__
d1axn__d1sf9a_:d1sf9a_
LSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNDEFTLNRIMVSRSEID
VDLGTENLYFQSNAMEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKITMAKAYLLNPEDY
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7.142857
[]
{"notes": "In 1axn, the 3-helix bundle uses helix 5 in the 1st duplicate, helix 1 in the 2nd duplicate, and helix 2 in the\n5th duplicate. This is an interface motif at the interface of three duplicates and in any one duplicate, the\narrangement of helix 1,2,5 is different than the arrangement in the interface motif.\n", "source_file": "d1axn__d1sf9a_.manual.ali"}
d1b05a_d1lc0a2:d1b05a_-d1lc0a2
d1b05a_d1lc0a2
malisam
d1b05a_d1lc0a2:d1b05a_
d1b05a_d1lc0a2:d1lc0a2
LADKQTLVRNNGSEVQIEGVPESNVSRDLFEGNGAYKLKNWVVNERIVLERNVINQVTYLPIS
MEEFEFLRREVLGKELLKGSLRFTASPLEEERFGFPAFSGISRLTWLVSLFGELSLISATLEERKEDQYMKMTVQLETQNKGLLSWIEEKGPGLKRNRYVNFQFTSGSLEEVPSVGVN
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8.888889
[]
{"notes": "The motif in 1b05: a hybrid motif, because a beta-hairpin is absent in the other duplicate and thus insertion.\nThe motif in 1lc0: although \"Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain\" is a very variable fold, it is in SCOP a+b class and\ndoes not have any resemblance to Rossmann-like structures. 1b05 is in a/b class and is Rossmann-like. \nSo these two motifs are analogs.\n", "source_file": "d1b05a_d1lc0a2.manual.ali"}
d1b05a_d1nkia_:d1b05a_-d1nkia_
d1b05a_d1nkia_
malisam
d1b05a_d1nkia_:d1b05a_
d1b05a_d1nkia_:d1nkia_
LADKQTLVRNNGSEVQIEGVPESNVSRDLFEGNGAYKLKNWVVNERIVLERNVINQVTYLPIS
MLTGLNHLTLAVADLPASIAFYRDLLGFRLEARWDQGAYLELGSLWLCLSREPQYGG
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8.695652
[]
{"notes": "The babbb motif in 1b05: a hybrid motif, because a beta-hairpin is absent in the majority of homologs in this superfamily and therefore is an insertion. Other parts of the motif come from the core of this superfamily.\nThe babbb motif in 1nki: a core motif.\nThus, these two motifs are analogs.\n", "source_file": "d1b05a_d1nkia_.manual.ali"}
d1b0pa2d1k0da2:d1b0pa2-d1k0da2
d1b0pa2d1k0da2
malisam
d1b0pa2d1k0da2:d1b0pa2
d1b0pa2d1k0da2:d1k0da2
YVYVATVSMGYSKQQFLKVLKEAESFPGPSLVIAYATCINQGLRKYWPLFRYDPRLAAQGKNPFQLDSKAP
QPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPL
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10.416667
[]
{"notes": "The motif in 1b0p: hybrid, since the C-terminal beta-hairpin is absent in d1b0pa1, which is the other module on the same chain and in the same superfamily.\n", "source_file": "d1b0pa2d1k0da2.manual.ali"}
d1b3qa2d1bia_2:d1b3qa2-d1bia_2
d1b3qa2d1bia_2
malisam
d1b3qa2d1bia_2:d1b3qa2
d1b3qa2d1bia_2:d1bia_2
TLAIICALLVKVNNLVYAIPIANIDTILSISKELEEMEAVIVRVGNRKYGIVVDDLLGQDDIVIKSL
FINRPVKLIIGDKEIFGISRGIDKQGALLLEQDGIIKPWMGGEISLR
[ [ 5, 3 ], [ 6, 4 ], [ 7, 5 ], [ 8, 6 ], [ 9, 7 ], [ 10, 8 ], [ 11, 9 ], [ 12, 10 ], [ 13, 11 ], [ 14, 12 ], [ 15, 13 ], [ 16, 14 ], [ 17, 15 ], [ 18, 16 ], [ 26, 19 ], [ 27, 20 ], [ 28, 21 ], [ 29, 22 ], [ 30, 23 ], [ 34, 24 ], [ 35, 25 ], [ 36, 26 ], [ 37, 27 ], [ 38, 28 ], [ 39, 29 ], [ 40, 30 ], [ 41, 31 ], [ 42, 32 ], [ 47, 33 ], [ 48, 34 ], [ 49, 35 ], [ 50, 36 ], [ 51, 37 ], [ 52, 38 ], [ 53, 41 ], [ 54, 42 ], [ 55, 43 ], [ 56, 44 ], [ 57, 45 ], [ 58, 46 ] ]
0
[]
{"notes": "The motif in 1b3q: interface motif involving the two duplicates; crossed connection;\nThe motif in 1bia: a stand-along barrel by itself.\n", "source_file": "d1b3qa2d1bia_2.manual.ali"}
d1b62a2d1i6pa_:d1b62a2-d1i6pa_
d1b62a2d1i6pa_
malisam
d1b62a2d1i6pa_:d1b62a2
d1b62a2d1i6pa_:d1i6pa_
ATRIDIDIERGGRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAIC
VEHIIICGHYGCGGVQAAVENPELGLINNWLLHIRDIWFKHSSLLGEMPQERRLDTLCELNVMEQVYNLGHSTIMQSAWKRGQKVTIHGWAYGIHDGLLRDLDVTATNRETLEQRYRHGISNLKLK
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12.5
[]
{"notes": "The motif in 1b62: compare d1b62a2 and d1amw__ (same superfamily), one strand and one helix is insertion. Hybrid motif. second helix too far away.\nThe core of this fold looks like a circularly permuted ferredoxin. The motif uses one edge strand of the ferredoxin core and the C-terminal extensions.\n", "source_file": "d1b62a2d1i6pa_.manual.ali"}
d1b6ra1d1k8kd1:d1b6ra1-d1k8kd1
d1b6ra1d1k8kd1
malisam
d1b6ra1d1k8kd1:d1b6ra1
d1b6ra1d1k8kd1:d1k8kd1
PLTHNLHQDGILRTSVAFPNPSVMINLIGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWAQSKFG
NKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSISLKFYKELQAHGADELLKRVYGSYLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNCMILLEVNNRIIEETLALKFENAAAG
[ [ 0, 2 ], [ 1, 3 ], [ 2, 4 ], [ 3, 5 ], [ 4, 6 ], [ 5, 7 ], [ 6, 8 ], [ 7, 9 ], [ 8, 10 ], [ 9, 16 ], [ 10, 17 ], [ 11, 18 ], [ 13, 19 ], [ 14, 20 ], [ 15, 21 ], [ 16, 22 ], [ 17, 23 ], [ 20, 27 ], [ 21, 28 ], [ 22, 29 ], [ 23, 30 ], [ 24, 31 ], [ 25, 32 ], [ 26, 33 ], [ 27, 34 ], [ 28, 35 ], [ 29, 64 ], [ 30, 65 ], [ 31, 66 ], [ 32, 67 ], [ 33, 68 ], [ 34, 69 ], [ 35, 70 ], [ 36, 71 ], [ 37, 72 ], [ 38, 73 ], [ 43, 79 ], [ 44, 80 ], [ 45, 81 ], [ 46, 82 ], [ 47, 83 ], [ 48, 84 ], [ 49, 85 ], [ 50, 86 ], [ 51, 87 ], [ 52, 88 ], [ 53, 89 ], [ 54, 90 ], [ 55, 91 ], [ 59, 102 ], [ 60, 103 ], [ 61, 104 ], [ 62, 105 ], [ 63, 106 ], [ 64, 107 ], [ 65, 108 ], [ 66, 109 ], [ 67, 110 ], [ 68, 111 ], [ 69, 112 ], [ 70, 113 ], [ 71, 114 ] ]
12.903226
[]
{"notes": "The motif in 1b6r: motif occurs at the interface of the ATP-grasp fold and Barrel-sandwich hybrid fold. interface motif;\n", "source_file": "d1b6ra1d1k8kd1.manual.ali"}
d1b6ra1d1v97a4:d1b6ra1-d1v97a4
d1b6ra1d1v97a4
malisam
d1b6ra1d1v97a4:d1b6ra1
d1b6ra1d1v97a4:d1v97a4
PLTHNLHQDGILRTSVAFPNPSVMINLIGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWAQSKFG
DEFFSAFKQASRREDDIAKVTCGMRVLFQPGSMQVKELALCYGGMADRTISALKTTQKQLSKFWNEKLLQDVCAGLAEELSLSPDAPGGMIEFRRTLTLSFFFKFYLTVLKKLG
[ [ 0, 1 ], [ 1, 2 ], [ 2, 3 ], [ 3, 4 ], [ 4, 5 ], [ 5, 6 ], [ 6, 7 ], [ 7, 8 ], [ 8, 9 ], [ 12, 20 ], [ 13, 21 ], [ 14, 22 ], [ 15, 23 ], [ 16, 24 ], [ 17, 25 ], [ 18, 26 ], [ 19, 36 ], [ 20, 37 ], [ 21, 38 ], [ 22, 39 ], [ 23, 40 ], [ 24, 41 ], [ 25, 42 ], [ 26, 43 ], [ 30, 45 ], [ 31, 46 ], [ 32, 47 ], [ 33, 48 ], [ 34, 49 ], [ 35, 50 ], [ 36, 51 ], [ 40, 67 ], [ 41, 68 ], [ 42, 69 ], [ 43, 70 ], [ 44, 71 ], [ 45, 72 ], [ 46, 73 ], [ 47, 74 ], [ 48, 75 ], [ 49, 76 ], [ 50, 77 ], [ 51, 78 ], [ 52, 79 ], [ 53, 80 ], [ 56, 90 ], [ 57, 91 ], [ 58, 92 ], [ 59, 93 ], [ 60, 94 ], [ 61, 95 ], [ 62, 96 ], [ 63, 97 ], [ 64, 98 ], [ 65, 99 ], [ 66, 100 ], [ 67, 101 ], [ 68, 102 ], [ 69, 103 ], [ 70, 104 ], [ 71, 105 ] ]
8.196721
[]
{"notes": "The motif in 1b6r: motif occurs at the interface of the ATP-grasp fold and 'Barrel-sandwich hybrid' fold.\nThe motif in 1v97: stand-along, core motif.\n", "source_file": "d1b6ra1d1v97a4.manual.ali"}
d1ce8a6d1di2a_:d1ce8a6-d1di2a_
d1ce8a6d1di2a_
malisam
d1ce8a6d1di2a_:d1ce8a6
d1ce8a6d1di2a_:d1di2a_
HTGDSITVAPAQTIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALRGL
MPVGSLQELAVQKGWRLPEYTVAQESGPPHKREFTITCRVETFVETGSGTSKQVAKRVAAEKLLTKFKT
[ [ 3, 17 ], [ 4, 18 ], [ 5, 19 ], [ 6, 20 ], [ 7, 21 ], [ 8, 22 ], [ 14, 31 ], [ 15, 32 ], [ 16, 33 ], [ 17, 34 ], [ 18, 35 ], [ 19, 36 ], [ 20, 37 ], [ 21, 38 ], [ 22, 39 ], [ 23, 40 ], [ 42, 41 ], [ 43, 42 ], [ 44, 43 ], [ 45, 44 ], [ 46, 45 ], [ 47, 46 ], [ 48, 47 ], [ 49, 48 ], [ 50, 49 ], [ 51, 50 ], [ 52, 51 ], [ 53, 52 ], [ 54, 53 ], [ 55, 54 ], [ 56, 55 ], [ 57, 56 ], [ 58, 57 ], [ 59, 58 ], [ 60, 59 ], [ 61, 60 ], [ 62, 61 ], [ 63, 62 ] ]
18.421053
[]
{"notes": "The motif in 1ce8 uses one strand from the ATP-grasp core and two strands and one helix from C-terminal extension. Comparing d1ce8a6 with d1gsa_2\n(different family same superfamily), the C-terminal extension is not present in d1gsa_2. So this is a hybrid motif. And it is analogous to real\ndsRBD domains.\n", "source_file": "d1ce8a6d1di2a_.manual.ali"}
d1chma1d1g62a_:d1chma1-d1g62a_
d1chma1d1g62a_
malisam
d1chma1d1g62a_:d1chma1
d1chma1d1g62a_:d1g62a_
FGRPYALVVTEDDVISISANIDGGQPWRRTVGTDNIVYTDWQRDNYFAAIQQALPKA
EIGVFSKLTNTYCLVAVGGSENFYSAFEAELGDAIPIVHTTIAGTRIIGRMTAGNRRGLLVPTQTTDQELQHLRNSLPDSVKIQRVEER
[ [ 3, 4 ], [ 4, 5 ], [ 5, 6 ], [ 6, 7 ], [ 7, 8 ], [ 8, 9 ], [ 13, 10 ], [ 14, 11 ], [ 15, 12 ], [ 16, 13 ], [ 17, 14 ], [ 18, 15 ], [ 19, 16 ], [ 20, 17 ], [ 21, 18 ], [ 22, 19 ], [ 23, 20 ], [ 24, 21 ], [ 25, 22 ], [ 26, 23 ], [ 27, 24 ], [ 28, 25 ], [ 29, 26 ], [ 32, 34 ], [ 33, 35 ], [ 34, 36 ], [ 35, 37 ], [ 36, 38 ], [ 37, 39 ], [ 38, 40 ], [ 39, 41 ], [ 43, 66 ], [ 44, 67 ], [ 45, 68 ], [ 46, 69 ], [ 47, 70 ], [ 48, 71 ], [ 49, 72 ], [ 50, 73 ], [ 51, 74 ], [ 52, 75 ], [ 53, 76 ] ]
11.904762
[]
{"notes": "The motif in 1chm: one helix and one strand do not belong to the RNaseH core. The \"Creatinase/prolidase N-terminal domain\" superfamily has only two\nproteins, and in the other protein (1n51) the inserted strand and helix are much deteriorated. Strictly speaking, this motif may not be a hybrid,\nsince it is present in all members in this superfamily. \nHowever, since d1chma1 and d1g62a_ are drastically different structures, the motif in d1chma1 and the motif in d1g62a_ are very unlikely to be\nhomologs and are probably analogs.\n", "source_file": "d1chma1d1g62a_.manual.ali"}
d1cs1a_d1q8ia1:d1cs1a_-d1q8ia1
d1cs1a_d1q8ia1
malisam
d1cs1a_d1q8ia1:d1cs1a_
d1cs1a_d1q8ia1:d1q8ia1
AGAVLTNTGMSAIHLVTTVFLDLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTG
QESVAFIPADQVPRAQHILQGEQGFRLTPLALKDFHRQPVYGLYCRAHRQLMNYEKRLREGGVTVYEADVR
[ [ 0, 1 ], [ 1, 2 ], [ 2, 3 ], [ 3, 4 ], [ 4, 5 ], [ 5, 6 ], [ 6, 7 ], [ 8, 8 ], [ 9, 9 ], [ 10, 10 ], [ 11, 11 ], [ 12, 12 ], [ 13, 13 ], [ 14, 14 ], [ 15, 15 ], [ 16, 16 ], [ 17, 17 ], [ 18, 18 ], [ 19, 19 ], [ 21, 23 ], [ 22, 24 ], [ 23, 25 ], [ 24, 26 ], [ 25, 27 ], [ 26, 28 ], [ 27, 29 ], [ 28, 30 ], [ 37, 37 ], [ 38, 38 ], [ 39, 39 ], [ 40, 40 ], [ 41, 41 ], [ 42, 42 ], [ 43, 43 ], [ 44, 44 ], [ 45, 45 ], [ 46, 46 ], [ 47, 47 ], [ 48, 48 ], [ 49, 49 ], [ 50, 50 ], [ 51, 51 ], [ 52, 52 ], [ 53, 53 ], [ 54, 54 ], [ 55, 55 ], [ 56, 56 ], [ 57, 57 ], [ 58, 58 ], [ 59, 59 ], [ 60, 60 ], [ 61, 61 ], [ 62, 62 ], [ 63, 63 ], [ 64, 64 ] ]
7.272727
[]
{"notes": "The motif in 1cs1: Although each family in the PLP-dependent transferases superfamily has this motif, this is a hybrid, because PLP-dependent\ntransferases superfamily is homologous to some flavodoxin proteins. So this motif is a hybrid between the Rossmann-like core and the insertions, and\nis therefore analogous to ancient folds like ferredoxin.\n", "source_file": "d1cs1a_d1q8ia1.manual.ali"}
d1d7ba_d1svb_2:d1d7ba_-d1svb_2
d1d7ba_d1svb_2
malisam
d1d7ba_d1svb_2:d1d7ba_
d1d7ba_d1svb_2:d1svb_2
GAQSTEFIGEVVAPIASKWIGIALGGAMNNDLLLVAWANGNQIVSSTRWATGYVQPTAYTGTATLTTLPETTINSTHWKWVFRCQGCTEWN
SRCTHLENRDFVTGTQGTTRVTLVLELGGCVTITAEGKPSMDVWLDAIYQENPAKTREYCLHAKLSDTKVAARCPTMGPATLAEEHQGGTVCKRDQSDRGWGNHCGLFGKGSIVACVKAACEAKKKATGHVYDANKIVYTVKVEPHTGDYVAANETHSGRKTASFTISSEKTILTMGEYGDVSLLCRVASGVDLAQTVILELDKTVEHLPTAWQVHRDWFNDLALPWKHEGAQNWNNAERLVEFGAPHAVKMDVYNLGDQTGVLLKALAGVPVAHIEGTKYHLKSGHVTCEVGLEKLKMKGL
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8.77193
[]
{"notes": "The motif in 1d7b: uses part of the Ig core and some inserted strands; hybrid motif. The most important feature in Ig fold is the\ninterlock composed of strands 2, 3, 5, 6 (if strands in a classic Ig are numbered from 1 to 7), like two scissors arranged mouth-to-mouth.\nThe motif in 1svb: the first domain in 1svb is almost all meander, so it cannot be homologous to Ig-like proteins.\n", "source_file": "d1d7ba_d1svb_2.manual.ali"}
d1dc1a_d1nf2a_:d1dc1a_-d1nf2a_
d1dc1a_d1nf2a_
malisam
d1dc1a_d1nf2a_:d1dc1a_
d1dc1a_d1nf2a_:d1nf2a_
GALAQQKLTRAIISALDIANIPYKWLDSRDKKYTNWMDKPEDDYELETFAKGISWTINGKHRTLMYNITVSL
EKIPPEVAKDIIEYIKPLNVHWQAYIDDVLYSEKDNEEIKSYARHSNVDYRVEPNLSELVSKMGTTKLLLIDTPERLDELKEILSERFKDVVKVFKSFPTYLEIVPKNV
[ [ 4, 3 ], [ 5, 4 ], [ 6, 5 ], [ 7, 6 ], [ 8, 7 ], [ 9, 8 ], [ 10, 9 ], [ 11, 10 ], [ 12, 11 ], [ 13, 12 ], [ 14, 13 ], [ 15, 14 ], [ 16, 15 ], [ 17, 16 ], [ 18, 17 ], [ 19, 18 ], [ 20, 19 ], [ 21, 20 ], [ 22, 21 ], [ 23, 22 ], [ 24, 23 ], [ 25, 24 ], [ 26, 25 ], [ 27, 26 ], [ 33, 27 ], [ 34, 28 ], [ 35, 29 ], [ 36, 30 ], [ 37, 31 ], [ 38, 32 ], [ 39, 52 ], [ 40, 53 ], [ 41, 54 ], [ 42, 55 ], [ 43, 56 ], [ 44, 57 ], [ 45, 58 ], [ 46, 59 ], [ 48, 63 ], [ 49, 64 ], [ 50, 65 ], [ 51, 66 ], [ 52, 67 ], [ 53, 68 ], [ 54, 69 ], [ 55, 70 ], [ 56, 71 ], [ 57, 72 ], [ 59, 99 ], [ 60, 100 ], [ 61, 101 ], [ 62, 102 ], [ 63, 103 ], [ 64, 104 ], [ 65, 105 ] ]
9.090909
[]
{"notes": "The motif in 1dc1: compared to d1ckqa_ (same superfamiliy), two strands are insertion;\nThe motif in 1nf2: the inserted domain appears like a circular-permuted ferredoxin, and most of the elements in the motif come from this\nferredoxin-like part.\n", "source_file": "d1dc1a_d1nf2a_.manual.ali"}
d1dc1a_d1rblm_:d1dc1a_-d1rblm_
d1dc1a_d1rblm_
malisam
d1dc1a_d1rblm_:d1dc1a_
d1dc1a_d1rblm_:d1rblm_
GALAQQKLTRAIISALDIANIPYKWLDSRDKKYTNWMDKPEDDYELETFAKGISWTINGKHRTLMYNITVSL
SMKTLPKERRFETFSYLPPLSDRQIAAQIEYMIEQGFHPLIEFNEHSNPEEFYWTMWKLPLFACAAPQQVLDEVRECRSEYGDCYIRVAGFDNIKECQTSSFIVHRPGR
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5.454545
[]
{"notes": "The motif in 1dc1: compared to d1ckqa_ (same superfamiliy), two strands are insertion;\n", "source_file": "d1dc1a_d1rblm_.manual.ali"}
d1dmza_d1hdha_:d1dmza_-d1hdha_
d1dmza_d1hdha_
malisam
d1dmza_d1hdha_:d1dmza_
d1dmza_d1hdha_:d1hdha_
QGVNPFFIGRDNRLSRVHCFIFKKRHAVGKSMYESPAQGLDDIWYCHTGTQGTKFLLQDGLGMLQEQRVVLKQTAEEKDLVKKL
ETEAAHDENTVTGWELFGMRAIRQGDWKAVYLPAPVGPATWQLYDLARDPGEIHDLADSQPGKLAELIEHWKRYVSETGVV
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11.764706
[]
{"notes": "The motif in 1dmz: compare to d1gxca_ (same family), the helix is the insertion. Can be analog to similar motifs in SCOP a+b class.\n", "source_file": "d1dmza_d1hdha_.manual.ali"}
d1ds1a_d1tig__:d1ds1a_-d1tig__
d1ds1a_d1tig__
malisam
d1ds1a_d1tig__:d1ds1a_
d1ds1a_d1tig__:d1tig__
TSVDCTAPGALATALDTFNAEGSEDGHLLLRGLPVEADADLPTTPSSTPAPEDRSLLTMEAMLGLVGRRLQPNYVMLACSRADHEPGDLLIVDNF
INVKEVRLSPTIEEHDFNTKLRNARKFLEKGDKVKATIRFKGRAITHKEIGQRVLDRLSEACADIAVVETAPKMDGRNMFLVLAPKND
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11.864407
[]
{"notes": "Comparing d1ds1a_ and d1e5sa_ (same superfamily, different family), one strand and one helix are insertions.\nThus the IF3-like motif in d1ds1a_ is a hybrid.\n", "source_file": "d1ds1a_d1tig__.manual.ali"}
d1dzka_d1qd1b2:d1dzka_-d1qd1b2
d1dzka_d1qd1b2
malisam
d1dzka_d1qd1b2:d1dzka_
d1dzka_d1qd1b2:d1qd1b2
FELSGKWITSYIGSSDTALIISNINVDEEGDKTIMTGLLGKGTDIEDQDLEKFKEVTRENGIPEENIVNIIERDDCPA
FLLAFNINLLSTREQAHRIALDLREQGRGKDQPGRLKKVQAIGWYLDEKNLAQVSTNLLDFEVTGLHTVFEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFLLQDEHRIRLVVNRLGLDSLAPFKPKERIIEYLV
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6.349206
[]
{"notes": "The motif in 1dzk: the last strand and the helix come from C-termianl extension, and the remaining part comes from the lipocalin core.\nHybrid motif.\n", "source_file": "d1dzka_d1qd1b2.manual.ali"}
d1dzta_d1kpf__:d1dzta_-d1kpf__
d1dzta_d1kpf__
malisam
d1dzta_d1kpf__:d1dzta_
d1dzta_d1kpf__:d1kpf__
MMIVIKTAIPDVLILEPKVFGDERGFFFESYNQQTFEELIGRKVTFGENAQGKLVRCAVENKRQLWIPE
DTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
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6.382979
[]
{"notes": "The motif in 1dzt: comparing d1dzta_ and 2phla1 (different family same superfamily, since domain arrangement in 2phla1 is the same as subunit\narrangement in d1dzta_ and the curvature of the beta-sheets are very similar in these two proteins), the insertion is in different position relative to the core\nstructure. Hybrid motif.\n", "source_file": "d1dzta_d1kpf__.manual.ali"}
d1e3pa3d1gpqa_:d1e3pa3-d1gpqa_
d1e3pa3d1gpqa_
malisam
d1e3pa3d1gpqa_:d1e3pa3
d1e3pa3d1gpqa_:d1gpqa_
NETHYAEAVIDNGAFGTRTIRFETGRLARQAAGSAVAYLDDDTMVLSATTASKNPNEIQVVATIMALNPDHLYDVVAINAASASTQLAGLP
DDLTISSLAKGETTKAAFNQMVQGHKLPAWVMKGGTYTPAQTVTLGDETYQVMSACKPHDCGSQRIAVMWSEKSNQMTGLFSTIDEKTSQEKLTWLNVNDALSIDGKTVLFAALTGSLENHPDGFNF
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12.121212
[]
{"notes": "The motif in 1e3p: the first two strands come from insertion, and the remaining part comes from the core. Hybrid motif.\n", "source_file": "d1e3pa3d1gpqa_.manual.ali"}
d1e3pa3d1tis__:d1e3pa3-d1tis__
d1e3pa3d1tis__
malisam
d1e3pa3d1tis__:d1e3pa3
d1e3pa3d1tis__:d1tis__
NETHYAEAVIDNGAFGTRTIRFETGRLARQAAGSAVAYLDDDNPDHLYDVVAINAASASTQLAGLPTEEVVAAGLDAAKPFIKVLCKAQADLAAKAAKP
NDRRQIVSAWNPAELKYMALPPCHMFYQFNVRNGYLDLQWYQRSVDVFLGLPFNIASYATLVHIVAKMCNLLGPIYGKQWRDFGGVDQIIEVIDRIKKLP
[ [ 2, 0 ], [ 3, 1 ], [ 4, 2 ], [ 5, 4 ], [ 6, 5 ], [ 7, 6 ], [ 8, 7 ], [ 9, 8 ], [ 10, 9 ], [ 17, 24 ], [ 18, 25 ], [ 19, 26 ], [ 20, 27 ], [ 21, 28 ], [ 22, 29 ], [ 23, 30 ], [ 24, 31 ], [ 32, 33 ], [ 33, 34 ], [ 34, 35 ], [ 35, 36 ], [ 36, 37 ], [ 37, 38 ], [ 38, 39 ], [ 39, 40 ], [ 46, 53 ], [ 47, 54 ], [ 48, 55 ], [ 49, 56 ], [ 50, 57 ], [ 51, 58 ], [ 52, 59 ], [ 53, 60 ], [ 54, 61 ], [ 55, 62 ], [ 56, 63 ], [ 57, 64 ], [ 58, 65 ], [ 59, 66 ], [ 60, 67 ], [ 61, 68 ], [ 62, 69 ], [ 72, 74 ], [ 73, 75 ], [ 74, 76 ], [ 75, 77 ], [ 76, 78 ], [ 77, 79 ], [ 78, 80 ], [ 79, 81 ], [ 80, 82 ], [ 82, 86 ], [ 83, 87 ], [ 84, 88 ], [ 85, 89 ], [ 86, 90 ], [ 87, 91 ], [ 88, 92 ], [ 89, 93 ], [ 90, 94 ], [ 91, 95 ], [ 92, 96 ], [ 93, 97 ], [ 94, 98 ], [ 95, 99 ] ]
6.153846
[]
{"notes": "The motif in 1e3p: first two strands come from insertion, third strand and first helix come from the core of the \"Ribosomal\nprotein S5 domain 2-like\" superfamily, last helix comes from C-terminal extension of another domain. hybrid motif.\n", "source_file": "d1e3pa3d1tis__.manual.ali"}
d1ecfa2d1unnc_:d1ecfa2-d1unnc_
d1ecfa2d1unnc_
malisam
d1ecfa2d1unnc_:d1ecfa2
d1ecfa2d1unnc_:d1unnc_
CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYP
HHVGVERTMAEDIHHWSECEAIIERLYPELERRLAKVKPDLLIARQGVKLKFDDFQQTTQEHVWPRLNKADLIATARKTWDERRGGRGVRLVGLHVTLLDPQMERQLVLGL
[ [ 0, 1 ], [ 1, 2 ], [ 2, 3 ], [ 3, 4 ], [ 4, 5 ], [ 5, 6 ], [ 6, 7 ], [ 7, 8 ], [ 8, 9 ], [ 9, 10 ], [ 10, 16 ], [ 11, 17 ], [ 12, 18 ], [ 13, 19 ], [ 14, 20 ], [ 15, 21 ], [ 16, 22 ], [ 17, 23 ], [ 18, 24 ], [ 19, 25 ], [ 20, 26 ], [ 21, 27 ], [ 22, 28 ], [ 23, 29 ], [ 24, 30 ], [ 25, 31 ], [ 26, 32 ], [ 27, 42 ], [ 28, 43 ], [ 29, 44 ], [ 30, 45 ], [ 31, 46 ], [ 32, 47 ], [ 33, 48 ], [ 34, 49 ], [ 35, 50 ], [ 36, 51 ], [ 37, 52 ], [ 38, 53 ], [ 39, 54 ], [ 40, 55 ], [ 41, 56 ], [ 42, 57 ], [ 43, 58 ], [ 44, 59 ], [ 45, 60 ], [ 46, 61 ], [ 47, 62 ], [ 48, 63 ], [ 49, 67 ], [ 50, 68 ], [ 51, 69 ], [ 52, 70 ], [ 53, 71 ], [ 54, 72 ], [ 55, 75 ], [ 56, 76 ], [ 57, 77 ], [ 58, 78 ], [ 59, 79 ], [ 60, 80 ], [ 61, 81 ], [ 62, 82 ], [ 63, 83 ], [ 64, 88 ], [ 65, 89 ], [ 66, 90 ], [ 67, 91 ], [ 68, 92 ], [ 69, 93 ], [ 70, 94 ], [ 71, 95 ], [ 72, 96 ], [ 73, 97 ], [ 74, 98 ] ]
10.666667
[]
{"notes": "The motif in 1ecf: compare d1ecfa2 (Class II glutamine amidotransferases) and d1pmab_ (Proteasome subunits), superimpose the two first strands,\nand it seems that at least two strands in the reverse-ferredoxin motif in d1ecfa2 are insertions. hybrid motif.\nThe bottom line is that Ntn and reverse-ferredoxin are drastically different folds. So the reverse_ferredoxin motif in Ntn is analog to real\nreverse_ferredoxin domains.\n", "source_file": "d1ecfa2d1unnc_.manual.ali"}
d1efdn_d1d1ra_:d1efdn_-d1d1ra_
d1efdn_d1d1ra_
malisam
d1efdn_d1d1ra_:d1efdn_
d1efdn_d1d1ra_:d1d1ra_
ARPLLLTTLIDPRHMLVFGPNSLFQEILDEYGIPNAWQGETNFWGSTAVSIDRLAAYKDVDVLCFDHD
KGDGVVRIQRQTSGRKGKGVCLITGVDLDDAELTKLAAELKKKCGCGGAVKDGVIEIQGDKRDLLKSLLEAKGMKVKLAGGLE
[ [ 2, 3 ], [ 3, 4 ], [ 4, 5 ], [ 5, 6 ], [ 6, 7 ], [ 7, 8 ], [ 8, 9 ], [ 9, 10 ], [ 10, 11 ], [ 12, 18 ], [ 13, 19 ], [ 14, 20 ], [ 15, 21 ], [ 16, 22 ], [ 17, 23 ], [ 18, 24 ], [ 44, 52 ], [ 45, 53 ], [ 46, 54 ], [ 47, 55 ], [ 48, 56 ], [ 49, 57 ], [ 50, 58 ], [ 51, 59 ], [ 52, 60 ], [ 53, 61 ], [ 54, 62 ], [ 55, 63 ], [ 56, 64 ], [ 57, 71 ], [ 58, 72 ], [ 59, 73 ], [ 60, 74 ], [ 61, 75 ], [ 62, 76 ], [ 63, 77 ], [ 64, 78 ], [ 65, 79 ], [ 66, 80 ], [ 67, 81 ] ]
15
[]
{"notes": "Comparing the two duplicates in 1efd, the motif results from some deletions in the Rossmann-like structure. Strictly speaking, this is not a hybrid motif.\nHowever, since eIF1-like fold is drastically different than Rossmann structures, the motif in 1efd and the motif in 1d1r are analogs.\n", "source_file": "d1efdn_d1d1ra_.manual.ali"}
d1efdn_d1r0va3:d1efdn_-d1r0va3
d1efdn_d1r0va3
malisam
d1efdn_d1r0va3:d1efdn_
d1efdn_d1r0va3:d1r0va3
ARPLLLTTLIDPRHMLVFGPNSLFQEILDEYGIPNAWQGETNFWGSTAVSIDRLAAYKDVDVLCFDHD
GEQKEELPEIAGVLSDEYVITKQTEIFSRYFYGSEKGDLVTLSLIESLYLLDLGKLNLLNADREELVKRAREVER
[ [ 0, 5 ], [ 1, 6 ], [ 2, 7 ], [ 3, 8 ], [ 4, 9 ], [ 5, 10 ], [ 6, 11 ], [ 7, 12 ], [ 8, 13 ], [ 9, 14 ], [ 10, 15 ], [ 12, 16 ], [ 13, 17 ], [ 14, 18 ], [ 15, 19 ], [ 16, 20 ], [ 17, 21 ], [ 18, 22 ], [ 44, 37 ], [ 45, 38 ], [ 46, 39 ], [ 47, 40 ], [ 48, 41 ], [ 49, 42 ], [ 50, 43 ], [ 51, 44 ], [ 52, 45 ], [ 53, 46 ], [ 54, 47 ], [ 55, 48 ], [ 56, 49 ], [ 57, 50 ], [ 60, 54 ], [ 61, 55 ], [ 62, 56 ], [ 63, 57 ], [ 64, 58 ], [ 65, 59 ] ]
10.526316
[]
{"notes": "Comparing the two duplicates in 1efd, the motif results from some deletions in the Rossmann-like structure. Strictly speaking, this is not a hybrid motif.\nHowever, since d1r0va3 (and its homolog d1w7aa4) is drastically different than Rossmann structures, the motif in 1efd and the motif in 1r0v are analogs.\n", "source_file": "d1efdn_d1r0va3.manual.ali"}
d1eg3a1d1paqa_:d1eg3a1-d1paqa_
d1eg3a1d1paqa_
malisam
d1eg3a1d1paqa_:d1eg3a1
d1eg3a1d1paqa_:d1paqa_
LDLLSLSAACDALDQHNLKQNDQPRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGE
DFEKEGIATVERAMENNHDLDTALLELNTLRMSMNVTYHEVRIATITALLRRVYHFIATQTLGPKDAVVKVFNQWGLLFKRQAFDEEEYIDLMNIIMEKIVEQSFDKPDLILFSALVSLYDNDIIEEDVIYKWWDNVSTDPRYDEVKKLTVKWVEWLQNAD
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10.606061
[]
{"notes": "In 1eg3, helix 1 and 4 in the first EF domain and helix 1 and 2 in the second EF domain form a right-handed superhelix, which is an interface motif.\n", "source_file": "d1eg3a1d1paqa_.manual.ali"}
d1ert__d1jr3d2:d1ert__-d1jr3d2
d1ert__d1jr3d2
malisam
d1ert__d1jr3d2:d1ert__
d1ert__d1jr3d2:d1jr3d2
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDD
LRAAYLLLGNDPLLLQESQDAVRQVAAAQGFEEHHTFSIDPNTDWNAIFSLCQAMSLFASRQTLLLLLPENGPNAAINEQLLTLTGLLHDDLLLIVRGNKL
[ [ 0, 2 ], [ 1, 3 ], [ 2, 4 ], [ 3, 5 ], [ 4, 6 ], [ 5, 7 ], [ 6, 14 ], [ 7, 15 ], [ 8, 16 ], [ 9, 17 ], [ 10, 18 ], [ 11, 19 ], [ 12, 20 ], [ 13, 21 ], [ 14, 22 ], [ 15, 23 ], [ 16, 24 ], [ 17, 25 ], [ 18, 26 ], [ 20, 60 ], [ 21, 61 ], [ 22, 62 ], [ 23, 63 ], [ 24, 64 ], [ 25, 65 ], [ 26, 66 ], [ 27, 67 ], [ 28, 68 ], [ 31, 73 ], [ 32, 74 ], [ 33, 75 ], [ 34, 76 ], [ 35, 77 ], [ 36, 78 ], [ 37, 79 ], [ 38, 80 ], [ 39, 81 ], [ 40, 82 ], [ 41, 83 ], [ 42, 84 ], [ 43, 85 ], [ 44, 86 ], [ 45, 87 ], [ 48, 88 ], [ 49, 89 ], [ 50, 90 ], [ 51, 91 ], [ 52, 92 ], [ 53, 93 ], [ 54, 94 ], [ 55, 95 ], [ 56, 96 ], [ 57, 97 ] ]
3.773585
[]
{"notes": "The motif in 1ert: comparing d1ert__ and d1h75a_ (same family, different protein), one strand and one helix are insertion. hybrid.\n", "source_file": "d1ert__d1jr3d2.manual.ali"}
d1fbxa_d1o08a_:d1fbxa_-d1o08a_
d1fbxa_d1o08a_
malisam
d1fbxa_d1o08a_:d1fbxa_
d1fbxa_d1o08a_:d1o08a_
PSLSKEAALVHEALVARGLETPIFSGLDYANFPKITGLSKINRIVQFFAQRPQVQERLTQQILIALQTLLGTN
TDTAEYHFRAWKALAEEIGINGVDRQFNEQLKGVSREDSLQKILDLADKKVSAEEFKELAKRKNDNYVKMIQDVSPADV
[ [ 3, 4 ], [ 4, 5 ], [ 5, 6 ], [ 6, 7 ], [ 7, 8 ], [ 8, 9 ], [ 9, 10 ], [ 10, 11 ], [ 11, 12 ], [ 12, 13 ], [ 13, 14 ], [ 14, 15 ], [ 15, 16 ], [ 16, 17 ], [ 17, 18 ], [ 18, 19 ], [ 19, 20 ], [ 20, 21 ], [ 27, 26 ], [ 28, 27 ], [ 29, 28 ], [ 30, 29 ], [ 31, 30 ], [ 32, 31 ], [ 42, 34 ], [ 43, 35 ], [ 44, 36 ], [ 45, 37 ], [ 46, 38 ], [ 47, 39 ], [ 48, 40 ], [ 49, 41 ], [ 50, 42 ], [ 51, 43 ], [ 52, 50 ], [ 53, 51 ], [ 54, 52 ], [ 55, 53 ], [ 56, 54 ], [ 57, 55 ], [ 58, 56 ], [ 59, 57 ], [ 60, 58 ], [ 61, 59 ], [ 62, 60 ], [ 63, 61 ], [ 64, 62 ], [ 65, 63 ], [ 66, 64 ], [ 67, 65 ], [ 68, 66 ], [ 69, 67 ], [ 70, 68 ] ]
3.773585
[]
{"notes": "The motif in 1fbx: 3-helix bundle uses a N-terminal inserted helix and the two core helices in the T-fold, so this is a hybrid motif. I\nkept the loop with the one-turn helix to make the topology up-and-down. Actually, this motif is more like a 4-helix bundle.\n", "source_file": "d1fbxa_d1o08a_.manual.ali"}
d1fy2a_d1qmha1:d1fy2a_-d1qmha1
d1fy2a_d1qmha1
malisam
d1fy2a_d1qmha1:d1fy2a_
d1fy2a_d1qmha1:d1qmha1
MELLLLSNSTLPGKAWLEHALPLIANQLNGRALYIGWSEGNWIQVSNGQAVLGGPN
ERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIHNLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTA
[ [ 0, 6 ], [ 1, 7 ], [ 2, 8 ], [ 3, 9 ], [ 4, 10 ], [ 5, 11 ], [ 6, 12 ], [ 7, 13 ], [ 16, 22 ], [ 17, 23 ], [ 18, 24 ], [ 19, 25 ], [ 20, 26 ], [ 21, 27 ], [ 22, 28 ], [ 23, 29 ], [ 24, 30 ], [ 25, 31 ], [ 26, 32 ], [ 27, 33 ], [ 32, 35 ], [ 33, 36 ], [ 34, 37 ], [ 35, 38 ], [ 36, 39 ], [ 37, 40 ], [ 38, 49 ], [ 39, 50 ], [ 40, 51 ], [ 41, 52 ], [ 42, 53 ], [ 43, 54 ], [ 44, 55 ], [ 45, 56 ], [ 46, 57 ], [ 47, 62 ], [ 48, 63 ], [ 49, 64 ], [ 50, 65 ], [ 51, 66 ], [ 52, 67 ], [ 53, 68 ], [ 54, 69 ] ]
2.325581
[]
{"notes": "The motif in 1fy2: part of the motif comes from the permuted flavodoxin core, part comes from C-terminal insertion. The insertion looks different in\ndifferent family, e.g. d1gpma2. So this is a hybrid motif and is analog to the thioredoxin core motif.\n", "source_file": "d1fy2a_d1qmha1.manual.ali"}
d1g99a1d1gqyb3:d1g99a1-d1gqyb3
d1g99a1d1gqyb3
malisam
d1g99a1d1gqyb3:d1g99a1
d1g99a1d1gqyb3:d1gqyb3
SSLKYQLIDMTNESALAVGLCERIGIDNSIITQKKFDGKKLEKLTDLPTHKDALEEVVKALTDDEFGVIK
RQVITYGFSEQADYRIEDYEQTGFQGHYTVICPNNERINVLLNVPGKHNALNATAALAVAKEEGIANEAILEALADFQ
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14.285714
[]
{"notes": "The motif in 1g99: compared to d1ig8a1 (same superfamily), two strands are insertion to the RNaseH core. hybrid motif.\nThe motif in 1gqy: although it looks like a dsRBD, the helix belongs to the Rossmann core because without it, half of the Rossmann sheet is\nnot covered. So this motif cannot be dsRBD and thus has nothing to do with RNaseH domains (RNaseH is thought to originated from dsRBD).\n", "source_file": "d1g99a1d1gqyb3.manual.ali"}
d1g99a1d1izna_:d1g99a1-d1izna_
d1g99a1d1izna_
malisam
d1g99a1d1izna_:d1g99a1
d1g99a1d1izna_:d1izna_
MKVLVINAGSSSLKYQLIDMTNESALAVGLCERIGIDNSIITQKKFDGKKLEKLTDLPTHKDALEEVVKALTDDEFGVIK
LKQWRDACDSALRAYVKDHYPNGFCTVYGKSIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVAAVLKIQVHYYEDGNVQLVSHKDIQDSVQVSSDVQTAKEFIKIIENAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGK
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7.042254
[]
{"notes": "The motif in 1g99: compared to d1ig8a1 (same superfamily), two strands are insertion to the RNaseH core. hybrid motif.\nThe motif in 1izn is the dimerization domain.\n", "source_file": "d1g99a1d1izna_.manual.ali"}
d1gc5a_d1omha_:d1gc5a_-d1omha_
d1gc5a_d1omha_
malisam
d1gc5a_d1omha_:d1gc5a_
d1gc5a_d1omha_:d1omha_
IERIHFHTYGYYLALTQYRGEEVRDALLFASLAAAAKAMKGNLEGLIDMVDRQLAFVPTKIVASPKSTVGIGDTISSSAFVSEFGMRKR
LSHMVLTRQDIGRAASYYGDASEWQGKGAEELGLSGEVDSKRFRELLAGNIGEGHRIMRSATRQDSKERIGLDLTFSAPKSVSLQALVAGDAEIIKAHDRAVARTLEQAEARAQARQKIQGKTRIETTGNLVIGKFRHETSRERDPQLHTHAVILNMTKRSDGQWRALKNDEIVKATRYLGAVYNAELAHELQKLGYQLRYGKDGNFDLAHIDRQQIEGFSKRTEQIAEWYAARGLDPNSVSLEQKQAAKVLSRAKKTSVDREALRAEWQATAKELGIDFS
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6.060606
[]
{"notes": "comparing d1gc5a_ & d1rkd__ (other family, but sure homolog to d1gc5a_, since they are very similar, including an inserted domain). The insertion\nthat forms part of the DCoH motif is absent in d1rkd__. So the motif in d1gc5a_ is a hybrid.\n", "source_file": "d1gc5a_d1omha_.manual.ali"}
d1gx3a_d1epaa_:d1gx3a_-d1epaa_
d1gx3a_d1epaa_
malisam
d1gx3a_d1epaa_:d1gx3a_
d1gx3a_d1epaa_:d1epaa_
GFEVERLSGRVVWMRADDAPLPAQTHNVLSVAVPGADGRYLVDVGFGGQTLTSPIRLEAGPVQQTRHEPYRLTRHGDDHTLAAQVRGEWQPLYTFTTEPRP
VKDFDISKFLGFWYEIAFASKMGTPGLAHKEEKMGAMVVELKENLLALTTTYYSEDHCVLEKVTATEGDGPAKFQVTRLSGKKEVVVEATDYLTYAIIDITSLVAGAVHRTMKLYSRSLDDNGEALYNFRKITSDHGFSETDLYILKHDLTCVKVLQSAA
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5.194805
[]
{"notes": "The motif in 1gx3: compare d1gx3a_ with classic cysteine proteinase papain d1ppn__ (same superfamily), half of the barrel in 1gx3 is\nabsent in 1ppn. So this is a hybrid motif and is analog to true barrels in all-beta class. Note that the cysteine proteinase superfamily is\nvery diverged in structures.\n", "source_file": "d1gx3a_d1epaa_.manual.ali"}
d1gx3a_d1pbya5:d1gx3a_-d1pbya5
d1gx3a_d1pbya5
malisam
d1gx3a_d1pbya5:d1gx3a_
d1gx3a_d1pbya5:d1pbya5
GFEVERLSGRVVWMRADDAPLPAQTHNVLSVAVPGADGRYLVDVGFGGQTLTSPIRLEAGPVQQTRHEPYRLTRHGDDHTLAAQVRGEWQPLYTFTTEPRP
PDAYADDASGAYVLAGRQPGRGDYTGRLVLKKAGEDYEVTMTLDFADGSRSFSGTGRILGAGEWRATLSDGTVTIRQIFALQDGRFSGRWHDADSDVIGGRLAAVKAD
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2.439024
[]
{"notes": "The motif in 1gx3: compare d1gx3a_ with classic cysteine proteinase papain d1ppn__ (same superfamily), half of the barrel in 1gx3 is absent in \n1ppn. So this is a hybrid motif and is analog to true barrels in all-beta class. Note that the cysteine proteinase superfamily is very\ndiverged in structures.\n", "source_file": "d1gx3a_d1pbya5.manual.ali"}
d1gxja_d1p5dx3:d1gxja_-d1p5dx3
d1gxja_d1p5dx3
malisam
d1gxja_d1p5dx3:d1gxja_
d1gxja_d1p5dx3:d1p5dx3
DEKYSLAVSVLLGGNSVVVETLDDAIRMKKKYRLNTRIATLDGELISGRGAITGGRE
IYPDRLLMLFAKDVVSRNPGADIIFDVKCTRRLIALISGYGGRPVMWKTGHSLIKKKMKETGALLAGEMSGHVFFKERWFGFDDGIYSAARLLEILSQD
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8.695652
[]
{"notes": "1gxj (Smc hinge domain) appears to have two duplicates. Each duplicate has three strands linked by two helices. The two duplicates swap the\nhelix between strand 1 and strand 2. So, although the SCOP fold \"Smc hinge domain\" only has one protein, I think its core is different from 1p5d,\nwhich is apparently a mini-Rossmann. Thus these two motifs are analogs.\n", "source_file": "d1gxja_d1p5dx3.manual.ali"}
d1h0hb_d1hz6b_:d1h0hb_-d1hz6b_
d1h0hb_d1hz6b_
malisam
d1h0hb_d1hz6b_:d1h0hb_
d1h0hb_d1hz6b_:d1hz6b_
SKGFFVDTTRCTACPTGAMNFGDLSEMEAMASARLAEIKAAYSDAKLCDPDDVRVIFLTAHNPKLYHEYAVA
EEVTIKANLIFANGSTQTAEFKGTFEKATSEAYAYADTLKKDNGEWTVDVADKGYTLNIKFAG
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6.25
[]
{"notes": "The motif in 1h0h: hybrid, see the \"structural drift\" paper.\n", "source_file": "d1h0hb_d1hz6b_.manual.ali"}
d1h5wa_d2cbla2:d1h5wa_-d2cbla2
d1h5wa_d2cbla2
malisam
d1h5wa_d2cbla2:d1h5wa_
d1h5wa_d2cbla2:d2cbla2
MAFPTTPTLELFAAELAELKEIISVNQNAQKTPTDAPYVVDKLNAQKNAVWNEMMTFLGIKNMAFPTTPTLELFAAELAELKEIISVNQNAQKTPTDAPYVVDKLNAQKNAVWNEMMTFLGIKN
PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGD
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6.756757
[]
{"notes": "The motif in 1h5w: 4-helix bundle uses corresponding parts from two monomers, so it is an interface motif.\n", "source_file": "d1h5wa_d2cbla2.manual.ali"}
d1h6da2d1kjka_:d1h6da2-d1kjka_
d1h6da2d1kjka_
malisam
d1h6da2d1kjka_:d1h6da2
d1h6da2d1kjka_:d1kjka_
DPMNRAAVKLIRENQLGKAVLLMDPATGYYQNLISVQTPGHANQSMMP
DRRIAITEAIQANIELFSGHDLPPNLYIRNNGYYCYRDPRTGKEFGLGR
[ [ 2, 0 ], [ 3, 1 ], [ 4, 2 ], [ 5, 3 ], [ 6, 4 ], [ 7, 5 ], [ 8, 6 ], [ 9, 7 ], [ 10, 8 ], [ 11, 9 ], [ 12, 10 ], [ 13, 11 ], [ 19, 24 ], [ 20, 25 ], [ 21, 26 ], [ 22, 27 ], [ 23, 28 ], [ 24, 29 ], [ 30, 30 ], [ 31, 31 ], [ 32, 32 ], [ 33, 33 ], [ 34, 34 ], [ 35, 35 ], [ 36, 36 ], [ 37, 37 ], [ 38, 38 ], [ 39, 41 ], [ 40, 42 ], [ 41, 43 ], [ 42, 44 ], [ 43, 45 ], [ 44, 46 ], [ 45, 47 ], [ 46, 48 ] ]
14.285714
[]
{"notes": "The motif in 1h6d: compared to d1lc0a2 (same superfamily), two strands are insertion. Hybrid. See d1drw_2 for the consensus of this fold as described\nin SCOP.\n", "source_file": "d1h6da2d1kjka_.manual.ali"}
d1hbnb2d1aisb2:d1hbnb2-d1aisb2
d1hbnb2d1aisb2
malisam
d1hbnb2d1aisb2:d1hbnb2
d1hbnb2d1aisb2:d1aisb2
NLEGIENALKTAELDLDIVGNAESIAAAAKEMIQVTEDDDPSARFDVAAEYSAAPLVTATAFVQAIINEFDVSMYDANMVKAAVLGR
TPKKLFVKPTDYVNKFADELGLSEKVRRRAIEILDEAYKRGLTSGKSPAGLVAAALYIASLLEGEKRTQREVAEVARVTEVTVRNRYKELVEKLKIKVPIA
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9.259259
[]
{"notes": "In 1hbn_B, the 4-helix bundle uses two helices from the ferredoxin core and two inserted helices. This is a hybrid motif.\n", "source_file": "d1hbnb2d1aisb2.manual.ali"}
d1hi9a_d1rpua_:d1hi9a_-d1rpua_
d1hi9a_d1rpua_
malisam
d1hi9a_d1rpua_:d1hi9a_
d1hi9a_d1rpua_:d1rpua_
FGVRHFYINDRPVGELGLNAYVAGYYDPLTPPDRPVLSIEFANTTVQFQAKDMLEAYQAMLVMTELAMRTSFC
NPLGFKESWGFGKVVFKRYLRYDRTEASLHRVLGSWTGDSVNYAASRFLGANQVGCTYSIRFRGVSVTISGGSRTLQHLCEMAIRSKQELLQLTPVEV
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6.451613
[]
{"notes": "The motif in 1hi9 comes from two insertions and a Rossmann helix. Hybrid motif.\n", "source_file": "d1hi9a_d1rpua_.manual.ali"}
d1hrda1d1rp3a3:d1hrda1-d1rp3a3
d1hrda1d1rp3a3
malisam
d1hrda1d1rp3a3:d1hrda1
d1hrda1d1rp3a3:d1rp3a3
KARSFGGSLVRPEATGYGSVYYVEAVMKHENDSKAVNAGGVLVSGFEMSQNSERLSWTAEEVDSKLHQVMTDIHDGSAAAAERYGLGY
MKNPYSNQIEREELILKYLPLVKAIATNIKKHLPEDVDIRDLISYGVIGLIKAVDNLSTENPKRAEAYIKLRIKGAIYDYLRSLDFG
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3.389831
[]
{"notes": "The motif in 1hrd: first helix is from the Rossmann core, the other two helices are from C-terminal extension. So this is a hybrid motif.\n", "source_file": "d1hrda1d1rp3a3.manual.ali"}
d1htjf_d1gnla_:d1htjf_-d1gnla_
d1htjf_d1gnla_
malisam
d1htjf_d1gnla_:d1htjf_
d1htjf_d1gnla_:d1gnla_
ADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLAADRSAPMDFALNTYMSHAGIRL
SNAMFCYQCQETVGNKGCTQVGVCGKKPETAALQDALIYVTKGLGQIATRLRAEGKAVDHRIDRLVTGNLFATITNANFDDDILAERVRMTCAAKKELAASLTDKSGLSDAALWEASEKSAMLAKAGTVGVMATT
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16.071429
[]
{"notes": "From the 1htj paper, the last three helices (helix 10-12) are an integral extension of the RGS fold with many hydrophobic interactions.\nThe last three helices are absent in other RGS, so they are insertions. The 3-helix motif in 1htj is a hybrid, using 1 helix from the\ninsertion and 2 helices from the RGS core. \n", "source_file": "d1htjf_d1gnla_.manual.ali"}
d1htjf_d1nhua_:d1htjf_-d1nhua_
d1htjf_d1nhua_
malisam
d1htjf_d1nhua_:d1htjf_
d1htjf_d1nhua_:d1nhua_
RPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQAGDPLRERQVAEKQLAALGDILSAYAADRSAPMDFALNTYMSHAGIRL
RDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS
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15.384615
[]
{"notes": "From the 1htj paper, the last three helices (helix 10-12) are an integral extension of the RGS fold with many hydrophobic interactions.\nThese three helices are absent in other RGS, so they are insertions. The 4-helix motif is a hybrid, using 2 helices from the RGS core and \n2 helices from the insertion.\n", "source_file": "d1htjf_d1nhua_.manual.ali"}
d1i9ea_d1mzka_:d1i9ea_-d1mzka_
d1i9ea_d1mzka_
malisam
d1i9ea_d1mzka_:d1i9ea_
d1i9ea_d1mzka_:d1mzka_
ATPYLFWYVQYPRQGLQLLLKYYSGDPVVQGVNGFEAEFSKSNSSFHLRKASVHWSDSAVYFCAVSGFA
LGSSWLFLEVIAGPAIGLQHAVNSTSSSKLPVKLGRVSPSDLALKDSEVSGKHAQITWNSTKFKWELVDMGSLNGTLVNSHSISHPDLGSRKWGNPVELASDDIITLGTTTKVYVRISSQNE
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10.169492
[]
{"notes": "The motif in 1i9e: two strands don't belong to the Ig core; hybrid motif.\nAlthough 1mzk is also Ig-like (the first strand in Ig fold is the 5th strand in 1mzk, according to SCOP's 11 strands numbering), the motif\nin 1i9e and the motif in 1mzk can not be homologs: if strands in Ig fold is counted from 1 to 7, all other strands are labeled as i\n(insertion), the motif in 1i9e is 34ii56 while the motif in 1mzk is iii127. So no homologous elements are superimposed.\n", "source_file": "d1i9ea_d1mzka_.manual.ali"}
d1i9ea_d1nppa1:d1i9ea_-d1nppa1
d1i9ea_d1nppa1
malisam
d1i9ea_d1nppa1:d1i9ea_
d1i9ea_d1nppa1:d1nppa1
ATPYLFWYVQYPRQGLQLLLKYYSGDPVVQGVNGFEAEFSKSNSSFHLRKASVHWSDSAVYFCAVSGFA
EEKVVIRAQGKEKYRLSLKGNARDISVLGKKGVTTFRIENGEVKVVESVEGDTCVNAPPISKPGQKITCKENKTEAKIVLD
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1.886792
[]
{"notes": "The motif in 1i9e: two strands don't belong to the Ig core; hybrid motif.\n", "source_file": "d1i9ea_d1nppa1.manual.ali"}
d1ihoa_d1ep7a_:d1ihoa_-d1ep7a_
d1ihoa_d1ep7a_
malisam
d1ihoa_d1ep7a_:d1ihoa_
d1ihoa_d1ep7a_:d1ep7a_
MLIIETLPLLRQQIRRLRMEGKRDVVVVSIFVYPRTLQEDCEKLNKRKVDLVFAPSV
GGSVIVIDSKAAWDAQLAKGKEEHKPIVVDFTATWCGPCKMIAPLFETLSNDYAGKVIFLKVDVDAVAAVAEAAGITAMPTFHVYKDGVKADDLVGASQDKLKALVAKHAAA
[ [ 1, 2 ], [ 2, 3 ], [ 3, 4 ], [ 4, 5 ], [ 5, 6 ], [ 6, 9 ], [ 7, 10 ], [ 8, 11 ], [ 9, 12 ], [ 10, 13 ], [ 11, 14 ], [ 12, 15 ], [ 13, 16 ], [ 14, 17 ], [ 15, 18 ], [ 16, 19 ], [ 17, 20 ], [ 18, 21 ], [ 19, 22 ], [ 20, 23 ], [ 24, 24 ], [ 25, 25 ], [ 26, 26 ], [ 27, 27 ], [ 28, 28 ], [ 29, 29 ], [ 30, 30 ], [ 31, 31 ], [ 35, 41 ], [ 36, 42 ], [ 37, 43 ], [ 38, 44 ], [ 39, 45 ], [ 40, 46 ], [ 41, 47 ], [ 42, 48 ], [ 43, 49 ], [ 44, 50 ], [ 45, 51 ], [ 46, 52 ], [ 47, 53 ], [ 50, 57 ], [ 51, 58 ], [ 52, 59 ], [ 53, 60 ], [ 54, 61 ], [ 55, 62 ], [ 56, 63 ] ]
14.583333
[]
{"notes": "The motif in 1iho: comparing d1ihoa_ with d1coza_ (different family same superfamily, note the split between the first and the fourth strands). The\ninsertion is one strand and one helix, which is absent in d1coza_.\nThe motif in 1ep7: one strand and one helix are N-terminal extension to the thioredoxin fold. hybrid motif.\n", "source_file": "d1ihoa_d1ep7a_.manual.ali"}
d1is8a_d1umwa1:d1is8a_-d1umwa1
d1is8a_d1umwa1
malisam
d1is8a_d1umwa1:d1is8a_
d1is8a_d1umwa1:d1umwa1
EDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQPAGVGVVIEATHKMNSKTVTSTMLGVFREDPKTREEFLTLIRS
PIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPR
[ [ 2, 12 ], [ 3, 13 ], [ 4, 14 ], [ 5, 15 ], [ 6, 16 ], [ 7, 17 ], [ 8, 18 ], [ 9, 19 ], [ 11, 20 ], [ 12, 21 ], [ 26, 22 ], [ 27, 23 ], [ 28, 24 ], [ 29, 25 ], [ 30, 26 ], [ 31, 27 ], [ 32, 28 ], [ 33, 29 ], [ 34, 30 ], [ 35, 31 ], [ 39, 32 ], [ 40, 33 ], [ 41, 34 ], [ 42, 35 ], [ 43, 36 ], [ 44, 37 ], [ 45, 38 ], [ 46, 39 ], [ 55, 41 ], [ 56, 42 ], [ 57, 43 ], [ 58, 44 ], [ 59, 45 ], [ 60, 46 ], [ 61, 47 ], [ 62, 48 ], [ 67, 65 ], [ 68, 66 ], [ 69, 67 ], [ 70, 68 ], [ 71, 69 ], [ 72, 70 ], [ 73, 71 ], [ 74, 72 ], [ 75, 73 ], [ 76, 74 ], [ 77, 75 ], [ 78, 76 ], [ 79, 77 ], [ 80, 78 ] ]
2
[]
{"notes": "The motif in 1is8: the helix is not in the T-fold core, compared to 1r51 or 1b66 (same superfamily). hybrid motif.\n", "source_file": "d1is8a_d1umwa1.manual.ali"}
d1izna_d1gkza1:d1izna_-d1gkza1
d1izna_d1gkza1
malisam
d1izna_d1gkza1:d1izna_
d1izna_d1gkza1:d1gkza1
RVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVP
LQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLA
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5.263158
[]
{"notes": "In 1izn, the 4-helix bundle uses corresponding parts in the two chains. interface motif. Note that the two chains are not identical, but they are in the same superfamily in SCOP.\nIn 1gkz, the 4-helix bundle is the core motif of that domain.\n", "source_file": "d1izna_d1gkza1.manual.ali"}
d1izna_d1keka2:d1izna_-d1keka2
d1izna_d1keka2
malisam
d1izna_d1keka2:d1izna_
d1izna_d1keka2:d1keka2
RVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVP
LFEDAAEYGFGMNMSMFARRTHLADLAAKALESDASGDVKEALQGWLAGKNDPIKSKEYGDKLKKLLAGQKDGLLGQIAAMSDLYTKK
[ [ 2, 15 ], [ 3, 16 ], [ 4, 17 ], [ 5, 18 ], [ 6, 19 ], [ 7, 20 ], [ 8, 21 ], [ 9, 22 ], [ 10, 23 ], [ 11, 24 ], [ 12, 25 ], [ 13, 26 ], [ 14, 27 ], [ 15, 28 ], [ 16, 29 ], [ 17, 30 ], [ 18, 34 ], [ 19, 35 ], [ 20, 36 ], [ 21, 37 ], [ 22, 39 ], [ 23, 40 ], [ 24, 41 ], [ 25, 42 ], [ 26, 43 ], [ 27, 44 ], [ 28, 45 ], [ 29, 46 ], [ 30, 47 ], [ 31, 48 ], [ 32, 49 ], [ 33, 50 ], [ 36, 52 ], [ 37, 53 ], [ 38, 54 ], [ 39, 55 ], [ 40, 56 ], [ 41, 57 ], [ 42, 58 ], [ 43, 59 ], [ 44, 60 ], [ 45, 61 ], [ 46, 62 ], [ 47, 63 ], [ 48, 64 ], [ 49, 65 ], [ 50, 66 ], [ 51, 67 ], [ 53, 72 ], [ 54, 73 ], [ 55, 74 ], [ 56, 75 ], [ 57, 76 ], [ 58, 77 ], [ 59, 78 ], [ 60, 79 ], [ 61, 80 ], [ 62, 81 ], [ 63, 82 ], [ 64, 83 ], [ 65, 84 ], [ 66, 85 ], [ 67, 86 ] ]
6.349206
[]
{"notes": "In 1izn, the 4-helix bundle uses corresponding parts in the two chains. interface motif. Note that the two chains are not identical, but they are in\nthe same superfamily in SCOP.\nIn 1kek, the 4-helix bundle is an individual subdomain inserted in the Rossmann structure.\n", "source_file": "d1izna_d1keka2.manual.ali"}
d1izna_d2gsca_:d1izna_-d2gsca_
d1izna_d2gsca_
malisam
d1izna_d2gsca_:d1izna_
d1izna_d2gsca_:d2gsca_
RVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVP
RPHERLDAWRDSMELVEMIYRLTEVFPDQERYGLTAQLRRAAVSIPSNIAEGAARDYSRFLSIARGSLSELDTQVQIAARLGYSRSEDDQSVRRQVDLVFAKLTALMNALRRR
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0
[]
{"notes": "In 1izn, the 4-helix bundle uses corresponding parts in the two chains. interface motif. Note that the two chains are not identical, but they are in the same superfamily in SCOP.\nIn 2gsc, the 4-helix bundle is an individual domain by itself.\n", "source_file": "d1izna_d2gsca_.manual.ali"}
d1j22a_d1m2aa_:d1j22a_-d1m2aa_
d1j22a_d1m2aa_
malisam
d1j22a_d1m2aa_:d1j22a_
d1j22a_d1m2aa_:d1m2aa_
VKVVVDSRELRSEVVKRLKLLGVKLEVKTLDVGDYIISEDVAIERKSTPEETAQYIFLIAKREQEE
AEFKHVFVCVQDRPPGHPQGSCAQRGSREVFQAFMEKIQTDPQLFMTTVITPTGCMNACMMGPVVVVYPDGVWYGQVKPEDVDEIVEKHLKGGEPVERLVISK
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14.285714
[]
{"notes": "The motif in 1j22: From the paper for 1j22, in Fig. 2, d1j22a_ have similar catalytic residues as Hjc (d1gefa_). Thus, d1j22a_ IS\nan endonuclease superfamily member. Therefore, one strand and one helix in the motif are insertion. In other families, the insertion adopts\ndifferent conformations, e.g. d1ckqa_. So this hybrid motif is analogous to thioredoxin.\n", "source_file": "d1j22a_d1m2aa_.manual.ali"}
d1jdbc2d1r9ca_:d1jdbc2-d1r9ca_
d1jdbc2d1r9ca_
malisam
d1jdbc2d1r9ca_:d1jdbc2
d1jdbc2d1r9ca_:d1r9ca_
DIPVFGICLGHQLLALASGPANLRVTHKSLFDGTLQGIHRTDKPAFSFQGHPEA
MIEGLSHMTFIVRDLERMTRILEGVFDAREVYASDTEQFSLSREKFFLIGDIWVAIMQGEKLAER
[ [ 2, 6 ], [ 3, 7 ], [ 4, 8 ], [ 5, 9 ], [ 6, 10 ], [ 7, 11 ], [ 8, 16 ], [ 9, 17 ], [ 10, 18 ], [ 11, 19 ], [ 12, 20 ], [ 13, 21 ], [ 14, 22 ], [ 15, 23 ], [ 16, 24 ], [ 17, 25 ], [ 18, 26 ], [ 21, 28 ], [ 22, 29 ], [ 23, 31 ], [ 24, 32 ], [ 25, 33 ], [ 32, 40 ], [ 33, 41 ], [ 34, 42 ], [ 36, 43 ], [ 37, 44 ], [ 38, 45 ], [ 39, 46 ], [ 40, 47 ], [ 41, 50 ], [ 42, 51 ], [ 43, 52 ], [ 44, 53 ], [ 45, 54 ], [ 46, 55 ], [ 47, 56 ], [ 48, 57 ], [ 49, 58 ], [ 50, 59 ], [ 51, 60 ] ]
12.195122
[]
{"notes": "Comparing d1jdbc2 with d1gg9a1 and d1g2ia_, they are homologs (same SCOP superfamily but different family). Note the angle of the helix after strand\n4. The motif in 1jdb is a hybrid because two strands in it do not belong to the flavodoxin core.\n", "source_file": "d1jdbc2d1r9ca_.manual.ali"}
d1jnwa_d1ew4a_:d1jnwa_-d1ew4a_
d1jnwa_d1ew4a_
malisam
d1jnwa_d1ew4a_:d1jnwa_
d1jnwa_d1ew4a_:d1ew4a_
LADPTAMVVATVSLLFPWHTLERQVMVIGEQIEFWQGGEHRLHDRFLYQRENDAWKIDRLAPKGGLRRRDLPADPLTLFERWLSQACEAK
MNDSEFHRLADQLWLTIEERLDDWDGDSDIDCEINGGVLTITFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWICDRSGETFWDLLEQAATQQAGETVSFR
[ [ 4, 29 ], [ 5, 30 ], [ 6, 31 ], [ 7, 32 ], [ 8, 33 ], [ 9, 34 ], [ 10, 35 ], [ 11, 36 ], [ 12, 37 ], [ 13, 38 ], [ 14, 39 ], [ 15, 40 ], [ 16, 41 ], [ 17, 42 ], [ 18, 43 ], [ 20, 44 ], [ 21, 45 ], [ 22, 46 ], [ 23, 47 ], [ 24, 48 ], [ 25, 49 ], [ 26, 50 ], [ 27, 51 ], [ 28, 52 ], [ 29, 59 ], [ 30, 60 ], [ 31, 61 ], [ 32, 62 ], [ 33, 63 ], [ 34, 64 ], [ 44, 65 ], [ 45, 66 ], [ 46, 67 ], [ 47, 68 ], [ 48, 69 ], [ 49, 70 ], [ 50, 71 ], [ 51, 72 ], [ 52, 77 ], [ 53, 78 ], [ 54, 79 ], [ 55, 80 ], [ 72, 84 ], [ 73, 85 ], [ 74, 86 ], [ 75, 87 ], [ 76, 88 ], [ 77, 89 ], [ 78, 90 ], [ 79, 91 ], [ 80, 92 ], [ 81, 93 ], [ 82, 94 ], [ 83, 95 ], [ 84, 96 ], [ 85, 97 ], [ 86, 98 ], [ 87, 99 ] ]
8.62069
[]
{"notes": "The motif in 1jnw: hybrid motif; compare to 1i0r, the core is a barrel;\n", "source_file": "d1jnwa_d1ew4a_.manual.ali"}
d1k2fa_d1svb_2:d1k2fa_-d1svb_2
d1k2fa_d1svb_2
malisam
d1k2fa_d1svb_2:d1k2fa_
d1k2fa_d1svb_2:d1svb_2
HKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRENGNLGINVTISMC
SRCTHLENRDFVTGTQGTTRVTLVLELGGCVTITAEGKPSMDVWLDAIYQENPAKTREYCLHAKLSDTKVAARCPTMGPATLAEEHQGGTVCKRDQSDRGWGNHCGLFGKGSIVACVKAACEAKKKATGHVYDANKIVYTVKVEPHTGDYVAANETHSGRKTASFTISSEKTILTMGEYGDVSLLCRVASGVDLAQTVILELDKTVEHLPTAWQVHRDWFNDLALPWKHEGAQNWNNAERLVEFGAPHAVKMDVYNLGDQTGVLLKALAGVPVAHIEGTKYHLKSGHVTCEVGLEKLKMKGL
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8.333333
[]
{"notes": "The motif in 1k2f: uses part of the Ig core and the inserted strand; hybrid motif. The most important feature in Ig fold is the interlock\ncomposed of strands 2, 3, 5, 6 (if strands in a classic Ig is numbered from 1 to 7), like two scissors arranged mouth-to-mouth.\nThe motif in 1svb: the first domain in 1svb is almost all meander, so it cannot be homologous to Ig-like proteins.\n", "source_file": "d1k2fa_d1svb_2.manual.ali"}
d1k9ka_d1abv__:d1k9ka_-d1abv__
d1k9ka_d1abv__
malisam
d1k9ka_d1abv__:d1k9ka_
d1k9ka_d1abv__:d1abv__
ACPLDQAIGLLVAIFHKYSGREGDKHTNFQEYVTFLGALALIYNEALKGACPLDQAIGLLVAIFHKYSGREGDKHTNFQEYVTFLGALALIYNEALKG
SEFITVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENGRLNALPDVLEQFIHLRAVSEAT
[ [ 1, 4 ], [ 2, 5 ], [ 3, 6 ], [ 4, 7 ], [ 5, 8 ], [ 6, 9 ], [ 7, 10 ], [ 8, 11 ], [ 9, 12 ], [ 10, 13 ], [ 11, 14 ], [ 12, 15 ], [ 13, 16 ], [ 14, 17 ], [ 15, 18 ], [ 16, 19 ], [ 17, 20 ], [ 18, 21 ], [ 27, 22 ], [ 28, 23 ], [ 29, 24 ], [ 30, 25 ], [ 31, 26 ], [ 32, 27 ], [ 33, 28 ], [ 34, 29 ], [ 35, 30 ], [ 36, 31 ], [ 37, 32 ], [ 38, 33 ], [ 39, 34 ], [ 40, 35 ], [ 41, 36 ], [ 42, 37 ], [ 43, 38 ], [ 44, 39 ], [ 50, 69 ], [ 51, 70 ], [ 52, 71 ], [ 53, 72 ], [ 54, 73 ], [ 55, 74 ], [ 56, 75 ], [ 57, 76 ], [ 58, 77 ], [ 59, 78 ], [ 60, 79 ], [ 61, 80 ], [ 62, 81 ], [ 63, 82 ], [ 80, 86 ], [ 81, 87 ], [ 82, 88 ], [ 83, 89 ], [ 84, 90 ], [ 85, 91 ], [ 86, 92 ], [ 87, 93 ], [ 88, 94 ], [ 89, 95 ], [ 90, 96 ], [ 91, 97 ], [ 92, 98 ], [ 93, 99 ], [ 94, 100 ], [ 95, 101 ], [ 96, 102 ], [ 97, 103 ] ]
4.411765
[]
{"notes": "The motif in 1k9k: 4-helix bundle comes from a dimer interface, so it is an interface motif.\n", "source_file": "d1k9ka_d1abv__.manual.ali"}
d1knza_d1rp3a3:d1knza_-d1rp3a3
d1knza_d1rp3a3
malisam
d1knza_d1rp3a3:d1knza_
d1knza_d1rp3a3:d1rp3a3
TQQMAVSIINSSFEAAVVAATSALENMGIEYDYQDIYSRVKNKFDFVMDDSGTQQMAVSIINSSFEAAVVAATSALENMGIEYDYQDIYSRVKNKFDFVMDDSG
MKNPYSNQIEREELILKYLPLVKAIATNIKKHLPEDVDIRDLISYGVIGLIKAVDNLSTENPKRAEAYIKLRIKGAIYDYLRSLDF
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11.267606
[]
{"notes": "The motif in 1knz: 4-helix bundle uses corresponding parts from the two monomers, so it is an interface motif.\n", "source_file": "d1knza_d1rp3a3.manual.ali"}
d1knza_d1vola1:d1knza_-d1vola1
d1knza_d1vola1
malisam
d1knza_d1vola1:d1knza_
d1knza_d1vola1:d1vola1
TQQMAVSIINSSFEAAVVAATSALENMGIEYDYQDIYSRVKNKFDFVMDDSGTQQMAVSIINSSFEAAVVAATSALENMGIEYDYQDIYSRVKNKFDFVMDDSG
AMMNAFKEITTMADRINLPRNKVDRTNNLFRQAYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVD
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13.432836
[]
{"notes": "The motif in 1knz: 4-helix bundle uses corresponding parts from the two monomers, so it is an interface motif.\n", "source_file": "d1knza_d1vola1.manual.ali"}
d1l6ra_d1ir6a_:d1l6ra_-d1ir6a_
d1l6ra_d1ir6a_
malisam
d1l6ra_d1ir6a_:d1l6ra_
d1l6ra_d1ir6a_:d1ir6a_
LTVSLLSGNVIPVVYALKIFLGINGPVFGENGGIMFDNDGSIKKFFSGEDKAFAVNKLKEMYSL
AKAIVLLDPEGHPGVMGIVASRILEATLRPVFLVAQGKGTVRSLAPISAVEALRSAEDLLLRYGGHKEAAGFAMDEALFPAFKARVEAYAARFPDPVREVALLDL
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15.384615
[]
{"notes": "The motif in 1l6r: two strands are insertions; hybrid motif in a Rossmann structure.\nIn 1ir6: comparing d1ir6a_ and d1k20a_ (same superfamily), domain 2 in these two homologs are not exactly the same. Anyway,\ndomain 2 does not have a Rossmann-like structure. So the motif in 1l6r and the motif in 1ir6 are analogs.\n", "source_file": "d1l6ra_d1ir6a_.manual.ali"}
d1l6ra_d1nrva_:d1l6ra_-d1nrva_
d1l6ra_d1nrva_
malisam
d1l6ra_d1nrva_:d1l6ra_
d1l6ra_d1nrva_:d1nrva_
LTVSLLSGNVIPVVYALKIFLGINGPVFGENGGIMFDNDGSIKKFFSGEDKAFAVNKLKEMYSL
IHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIR
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3.921569
[]
{"notes": "The motif in 1l6r: two strands are insertions; hybrid motif in a Rossmann structure.\nThe motif in 1nrv: core motif in SH2 fold.\n", "source_file": "d1l6ra_d1nrva_.manual.ali"}
d1lci__d1lla_1:d1lci__-d1lla_1
d1lci__d1lla_1
malisam
d1lci__d1lla_1:d1lci__
d1lci__d1lla_1:d1lla_1
ENSLQFFMPVLGALFIGGTAGEQLHKAMKRYALVPGTIATYAEYFEMSVRLAEAMKRYGLNT
HSDRLKNVGKLQPGAIFSCFHPDHLEEARHLYEVFWEAGDFNDFIEIAKEARTFVNEGLFAFAAEVAVLHRDDCKGLYVP
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11.111111
[]
{"notes": "The motif in 1lci: the first helix is a N-terminal extension, the second one is present in the other duplicate, the third one is a\nRossmann helix. So this is a hybrid motif, but needs circular permutation to make it into a common topology.\n", "source_file": "d1lci__d1lla_1.manual.ali"}
d1lq7a_d1gqea_:d1lq7a_-d1gqea_
d1lq7a_d1gqea_
malisam
d1lq7a_d1gqea_:d1lq7a_
d1lq7a_d1gqea_:d1gqea_
GSRVKALEEKVKALEEKVKALGGGGRIEELKKKWEELKKKIEELGGGGEVKKVEEEVKKLEEEIKKL
INPVNNRIQDLTERSDVLRGYLDYDAKKERLEEVNAELEQPDVWNEPERAQALGKERSSLEAVVDTLDQMKQGLEDVSGLLELAVEADDEETFNEAVAELDALEEKLAQLEFRR
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18.032787
[]
{"notes": "1lq7 is an artificial protein, so it is analog to the natural protein 1gqe.\n", "source_file": "d1lq7a_d1gqea_.manual.ali"}
d1lwda_d1a5t_1:d1lwda_-d1a5t_1
d1lwda_d1a5t_1
malisam
d1lwda_d1a5t_1:d1lwda_
d1lwda_d1a5t_1:d1a5t_1
DEMTRIIWQFIKEKLILPHVNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTLNTSDFLDTIKSNLDRALGRQ
DNWQARETLCQALAYSVPSGDWYSLLAALNHEQAPARLHWLATLLMDALKRVTNVDVPGLVAELANHLSPSRLQAILGDVCHIREQLMSVTGINRELLITDLLLRIEHYLQPGVVL
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8.333333
[]
{"notes": "The motif in 1lwd: the 4-helix bundle uses the first and the last helices in the core structure, the other two helices come from\nC-terminal extension. So this is a hybrid motif, but the topology is down-down-up-down.\n", "source_file": "d1lwda_d1a5t_1.manual.ali"}
d1m9na2d1j27a_:d1m9na2-d1j27a_
d1m9na2d1j27a_
malisam
d1m9na2d1j27a_:d1m9na2
d1m9na2d1j27a_:d1j27a_
SPGFINLCDALNAWQLVKELKQALGIPAAASFKHVSPAGAAVGIPESAVRDLIVASIAVKYTQSNSVCYAKDGQVIGIGAGQQ
ARSLKEKRALIKPALERLKARFPVSAARLYGLDAWGYEVVGFTLLGNDPAWVEETMRAAARFLAEAGGFQVALEEFRLEAFELMKAYLGLYTARLETP
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9.230769
[]
{"notes": "The motif in 1m9n: occurs in the interface of the two duplicates.\n", "source_file": "d1m9na2d1j27a_.manual.ali"}
d1miwa2d1gyfa_:d1miwa2-d1gyfa_
d1miwa2d1gyfa_
malisam
d1miwa2d1gyfa_:d1miwa2
d1miwa2d1gyfa_:d1gyfa_
YDAYFVGGRPIGDVDIATSARSLEEDLKRRDFTMNAIAMDEYGTIIDPFG
DVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT
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10.869565
[]
{"notes": "The motif in 1miw: compare 1miw to d1fa0a4 (different family, same superfamily), a C-terminal beta-hairpin is insertion. \nThe motif in 1gyf: core motif.\n", "source_file": "d1miwa2d1gyfa_.manual.ali"}
d1mk5a_d1efub2:d1mk5a_-d1efub2
d1mk5a_d1efub2
malisam
d1mk5a_d1efub2:d1mk5a_
d1mk5a_d1efub2:d1efub2
TDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTETDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTE
VAADGVIKTKIDGNYGIILEVNCQTDFVAKDAKIGENINIRRVAALEGDVLGSYQHGARIGVLVAAKGADEELLKEHNAEVTGFIRFEVGEGIEKVET
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8.695652
[]
{"notes": "The motif in 1mk5: it uses corresponding core elements in two monomers and is an interface motif.\nThe motif in 1efu: it uses corresponding core elements in two duplicates and is an interface motif. \nThe two motifs are analogous because 1mk5 is a barrel but 1efu is a a+b structure.\n", "source_file": "d1mk5a_d1efub2.manual.ali"}
d1mw5a_d1bco_1:d1mw5a_-d1bco_1
d1mw5a_d1bco_1
malisam
d1mw5a_d1bco_1:d1mw5a_
d1mw5a_d1bco_1:d1bco_1
QPVKLYSNLPAPFYVLLPESDKALPYVRVSMEYQPVKLYSNLPAPFYVLLPESDKALPYVRVSMEY
TEEQKRMLLLPAEAVNVSRKGEFTLKVGGSLKGAKNVYYNMALMNAGVKKVVVRFDPQQLHSTVYCYTLDGRFICEAECL
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8.163265
[]
{"notes": "The motif in 1mw5: barrel formed by two monomers, interface motif.\n", "source_file": "d1mw5a_d1bco_1.manual.ali"}
d1n00a_d1aa7a_:d1n00a_-d1aa7a_
d1n00a_d1aa7a_
malisam
d1n00a_d1aa7a_:d1n00a_
d1n00a_d1aa7a_:d1aa7a_
DPAERDALLANEATKRWTSSNQVLMEIACTRYPEKYFEKVLRLAINRRGTDEGALTRVVCTRAEVD
MSLLTEVETYVLSIIPSGPLKAEIAQRLEDVFAGKNTDLEVLMEWLKTRPILSPLTKGILGFVFTLTVPSERGL
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7.407407
[]
{"notes": "In 1n00, the 4-helix bundle uses the first two helices in the 2nd duplicate and the first two helices in the 4th duplicate.\nIt occurs in the interface between two duplicates. Therefore, it is an interface motif.\n", "source_file": "d1n00a_d1aa7a_.manual.ali"}
d1n7va_d1izna_:d1n7va_-d1izna_
d1n7va_d1izna_
malisam
d1n7va_d1izna_:d1n7va_
d1n7va_d1izna_:d1izna_
AYYAVYKTDGYGGATCFIASGGAGISALVQLQDNSVLDVLYYSLPLSLGGSKAAIDEWVANNCGLF
LKQWRDACDSALRAYVKDHYPNGFCTVYGKSIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVAAVLKIQVHYYEDGNVQLVSHKDIQDSVQVSSDVQTAKEFIKIIENAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGK
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8.62069
[]
{"notes": "The motif in 1n7v: The helix is a deteriorated blade in the propeller. This is a hybrid motif and can be analog to similar motifs in\nSCOP a+b class.\n", "source_file": "d1n7va_d1izna_.manual.ali"}
d1nf2a_d1ptma_:d1nf2a_-d1ptma_
d1nf2a_d1ptma_
malisam
d1nf2a_d1ptma_:d1nf2a_
d1nf2a_d1ptma_:d1ptma_
NVHWQAYIDDVLYSEKDNEEIKSYARHSNVDYRVEPNLSELVSKMGTTKLLLIDT
AKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRADAVLAMYHDQGLPVLKYQGFGRGVNITLGLP
[ [ 0, 2 ], [ 1, 3 ], [ 2, 4 ], [ 3, 5 ], [ 4, 6 ], [ 5, 7 ], [ 6, 8 ], [ 7, 9 ], [ 8, 10 ], [ 9, 11 ], [ 10, 12 ], [ 11, 13 ], [ 12, 14 ], [ 13, 15 ], [ 14, 16 ], [ 15, 17 ], [ 17, 39 ], [ 18, 40 ], [ 19, 41 ], [ 20, 42 ], [ 21, 43 ], [ 22, 44 ], [ 23, 45 ], [ 24, 46 ], [ 25, 47 ], [ 26, 48 ], [ 27, 49 ], [ 28, 50 ], [ 30, 58 ], [ 31, 59 ], [ 32, 60 ], [ 33, 61 ], [ 34, 62 ], [ 35, 63 ], [ 36, 64 ], [ 37, 68 ], [ 38, 69 ], [ 39, 70 ], [ 40, 71 ], [ 41, 72 ], [ 42, 73 ], [ 43, 74 ], [ 44, 75 ], [ 45, 76 ], [ 47, 80 ], [ 48, 81 ], [ 49, 82 ], [ 50, 83 ], [ 51, 84 ], [ 52, 85 ], [ 53, 86 ], [ 54, 87 ] ]
7.692308
[]
{"notes": "The motif in 1nf2: compare 1nf2 with 1l6r (same family), the inserted subdomain is a circularly permuted ferredoxin in 1l6r. So the motif in 1nf2 is a hybrid.\nThe motif in 1ptm: occurs at the interface of the two duplicates, hybrid.\n", "source_file": "d1nf2a_d1ptma_.manual.ali"}
d1nkta3d1ldja1:d1nkta3-d1ldja1
d1nkta3d1ldja1
malisam
d1nkta3d1ldja1:d1nkta3
d1nkta3d1ldja1:d1ldja1
GKTLTCVLPAYLNALAGNETLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGAAALHLG
PMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA
[ [ 0, 17 ], [ 1, 18 ], [ 2, 19 ], [ 3, 20 ], [ 4, 21 ], [ 5, 22 ], [ 6, 23 ], [ 7, 24 ], [ 8, 25 ], [ 9, 26 ], [ 10, 27 ], [ 11, 28 ], [ 12, 29 ], [ 13, 30 ], [ 14, 31 ], [ 15, 32 ], [ 16, 33 ], [ 23, 39 ], [ 24, 40 ], [ 25, 41 ], [ 26, 42 ], [ 27, 43 ], [ 28, 44 ], [ 29, 45 ], [ 30, 46 ], [ 31, 47 ], [ 32, 48 ], [ 33, 49 ], [ 34, 50 ], [ 35, 51 ], [ 36, 52 ], [ 37, 53 ], [ 40, 54 ], [ 41, 55 ], [ 42, 56 ], [ 43, 57 ], [ 44, 58 ], [ 45, 59 ], [ 46, 60 ], [ 47, 61 ], [ 48, 62 ], [ 49, 63 ], [ 50, 64 ], [ 51, 65 ], [ 52, 66 ], [ 53, 67 ], [ 54, 68 ], [ 55, 69 ], [ 56, 70 ], [ 57, 71 ] ]
4
[]
{"notes": "In 1nkt, the 3-helix bundle uses one helix in the N-terminal extra all-alpha subdomain, one helix before the first strand in the\nRossmann-like fold (this helix can be considered as part of the Rossmann fold), and one helix after the P-loop. This is a hybrid motif, but\nthe topology is up-down-down. So we make a circular permutation.\n", "source_file": "d1nkta3d1ldja1.manual.ali"}
d1o02a_d1ihna_:d1o02a_-d1ihna_
d1o02a_d1ihna_
malisam
d1o02a_d1ihna_:d1o02a_
d1o02a_d1ihna_:d1ihna_
NQIFINNEWHDAGDKEDVDKAVKAARAAFQLGGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGF
SHMFSDCRFGSVTYRGREYRSDIVVHVDGSVTPRRKEISRRKYGTSHVMAEEELEELLEEKPESIIIGSGVHGALETGFRSDATVLPTCEAIKRYNEERSAGRRVAAIIHVTC
[ [ 0, 21 ], [ 1, 22 ], [ 2, 23 ], [ 3, 24 ], [ 4, 25 ], [ 5, 26 ], [ 6, 28 ], [ 7, 29 ], [ 8, 30 ], [ 9, 31 ], [ 10, 32 ], [ 11, 33 ], [ 12, 48 ], [ 13, 49 ], [ 14, 50 ], [ 15, 51 ], [ 16, 52 ], [ 17, 53 ], [ 18, 54 ], [ 19, 55 ], [ 20, 56 ], [ 21, 57 ], [ 22, 58 ], [ 23, 59 ], [ 24, 60 ], [ 34, 62 ], [ 35, 63 ], [ 36, 64 ], [ 37, 65 ], [ 38, 66 ], [ 39, 67 ], [ 40, 68 ], [ 41, 69 ], [ 42, 70 ], [ 43, 86 ], [ 44, 87 ], [ 45, 88 ], [ 46, 89 ], [ 47, 90 ], [ 48, 91 ], [ 49, 92 ], [ 50, 93 ], [ 51, 94 ], [ 52, 95 ], [ 53, 96 ], [ 54, 97 ], [ 55, 98 ], [ 56, 99 ], [ 57, 100 ], [ 58, 101 ], [ 59, 102 ], [ 63, 103 ], [ 64, 104 ], [ 65, 105 ], [ 66, 106 ], [ 67, 107 ], [ 68, 108 ], [ 69, 109 ], [ 70, 110 ] ]
10.169492
[]
{"notes": "The motif in 1o02: hybrid; uses N-terminal extension and the 2nd and 3rd strands in the Rossmann core.\nThe motif in 1ihn: there is only one structure in this SCOP fold. No homologs to compare with. But this fold is very different from Rossmann fold.\nSo these two motifs are analogs.\n", "source_file": "d1o02a_d1ihna_.manual.ali"}
d1o17d2d1ir6a_:d1o17d2-d1ir6a_
d1o17d2d1ir6a_
malisam
d1o17d2d1ir6a_:d1o17d2
d1o17d2d1ir6a_:d1ir6a_
PANAKYQLMGVFSKDHLDLLSKSAYELDFNKIILVYGEPGIDEVSPIGNTFMKIVSKRGIEEVKLNVKDEHVAEFIKINTAVALFALDRVG
AKAIVLLDPEGHPGVMGIVASRILEATLRPVFLVAQGKGTVRSLAPISAVEALRSAEDLLLRYGGHKEAAGFAMDEALFPAFKARVEAYAARFPDPVREVALLDL
[ [ 3, 0 ], [ 4, 1 ], [ 5, 2 ], [ 6, 3 ], [ 7, 4 ], [ 8, 5 ], [ 9, 6 ], [ 10, 7 ], [ 11, 10 ], [ 12, 11 ], [ 13, 12 ], [ 14, 13 ], [ 15, 14 ], [ 16, 15 ], [ 17, 16 ], [ 18, 17 ], [ 19, 18 ], [ 20, 19 ], [ 21, 20 ], [ 22, 21 ], [ 23, 22 ], [ 24, 23 ], [ 25, 24 ], [ 26, 25 ], [ 27, 27 ], [ 28, 28 ], [ 30, 29 ], [ 31, 30 ], [ 32, 31 ], [ 33, 32 ], [ 34, 33 ], [ 35, 34 ], [ 36, 35 ], [ 49, 36 ], [ 50, 37 ], [ 51, 38 ], [ 52, 39 ], [ 53, 40 ], [ 54, 41 ], [ 55, 42 ], [ 56, 43 ], [ 58, 67 ], [ 59, 68 ], [ 60, 69 ], [ 61, 70 ], [ 62, 71 ], [ 63, 72 ], [ 64, 73 ], [ 65, 74 ], [ 75, 75 ], [ 76, 76 ], [ 77, 77 ], [ 78, 78 ], [ 79, 79 ], [ 80, 80 ], [ 81, 81 ], [ 82, 82 ], [ 83, 83 ], [ 84, 84 ], [ 85, 85 ], [ 86, 86 ], [ 87, 87 ] ]
11.290323
[]
{"notes": "The motif in 1o17: compare to d2tpt_2 (same family); two strands are insertions; hybrid motif resulted from a helix-to-strand transition in a Rossmann structure.\nIn 1ir6, comparing d1ir6a_ and d1k20a_ (same superfamily), domain 2 in these two homologs are not exactly the same. Anyway, domain 2 does \nnot have a Rossmann-like structure. So the motif in 1o17 and the motif in 1ir6 are analogs.\n", "source_file": "d1o17d2d1ir6a_.manual.ali"}
d1o17d2d1jyra_:d1o17d2-d1jyra_
d1o17d2d1jyra_
malisam
d1o17d2d1jyra_:d1o17d2
d1o17d2d1jyra_:d1jyra_
PANAKYQLMGVFSKDHLDLLSKSAYELDFNKIILVYGEPGIDEVSPIGNTFMKIVSKRGIEEVKLNVKDEHVAEFIKINTAVALFALDRVG
GSMAWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDI
[ [ 8, 4 ], [ 9, 5 ], [ 10, 6 ], [ 11, 7 ], [ 12, 8 ], [ 13, 9 ], [ 15, 10 ], [ 16, 11 ], [ 17, 12 ], [ 18, 13 ], [ 19, 14 ], [ 20, 15 ], [ 21, 16 ], [ 22, 17 ], [ 23, 18 ], [ 24, 19 ], [ 25, 20 ], [ 26, 21 ], [ 27, 22 ], [ 28, 23 ], [ 29, 24 ], [ 30, 25 ], [ 31, 26 ], [ 32, 27 ], [ 33, 28 ], [ 34, 29 ], [ 35, 30 ], [ 36, 31 ], [ 37, 32 ], [ 38, 33 ], [ 47, 37 ], [ 48, 38 ], [ 49, 39 ], [ 50, 40 ], [ 51, 41 ], [ 52, 42 ], [ 53, 43 ], [ 54, 44 ], [ 55, 45 ], [ 56, 46 ], [ 57, 47 ], [ 58, 48 ], [ 59, 49 ], [ 60, 50 ], [ 61, 51 ], [ 62, 52 ], [ 63, 53 ], [ 64, 54 ], [ 65, 55 ], [ 66, 56 ], [ 73, 71 ], [ 74, 72 ], [ 75, 73 ], [ 76, 74 ], [ 77, 75 ], [ 78, 76 ], [ 79, 77 ], [ 80, 78 ], [ 81, 79 ], [ 82, 80 ], [ 83, 81 ], [ 84, 82 ] ]
4.83871
[]
{"notes": "The motif in 1o17: compare to d2tpt_2 (same family); two strands are insertions; hybrid motif resulted from a helix-to-strand transition in a Rossmann structure.\nThe motif in 1jyr: core motif in SH2 fold.\n", "source_file": "d1o17d2d1jyra_.manual.ali"}
d1ogqa_d1fjgc1:d1ogqa_-d1fjgc1
d1ogqa_d1fjgc1
malisam
d1ogqa_d1fjgc1:d1ogqa_
d1ogqa_d1fjgc1:d1fjgc1
ELCNPQDKQALLQIKKDLGNPTTLSSWLPTTDCCNRTWLGVLCDTDTQTYRVNNLDLSGLNLPKPYPIPSSLANLPYLNFLYIGGIN
GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAGLARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVALNVQEV
[ [ 3, 31 ], [ 4, 32 ], [ 5, 33 ], [ 6, 34 ], [ 7, 35 ], [ 8, 36 ], [ 9, 37 ], [ 10, 38 ], [ 11, 39 ], [ 12, 40 ], [ 13, 41 ], [ 14, 42 ], [ 15, 43 ], [ 16, 44 ], [ 17, 45 ], [ 18, 46 ], [ 39, 54 ], [ 40, 55 ], [ 41, 56 ], [ 42, 57 ], [ 43, 58 ], [ 49, 60 ], [ 50, 61 ], [ 51, 62 ], [ 53, 63 ], [ 54, 64 ], [ 55, 65 ], [ 56, 66 ], [ 57, 67 ], [ 58, 68 ], [ 68, 87 ], [ 69, 88 ], [ 70, 89 ], [ 71, 90 ], [ 72, 91 ], [ 73, 92 ], [ 74, 93 ], [ 75, 94 ], [ 76, 95 ], [ 77, 96 ], [ 78, 97 ], [ 79, 98 ], [ 80, 99 ], [ 81, 100 ], [ 82, 101 ], [ 83, 102 ], [ 84, 103 ] ]
10.638298
[]
{"notes": "The motif in 1ogq: compare d1ogqa_ to d1g9ua_ (same superfamily), one strand is insertion. hybrid motif.\nThe bottom line is that Leucine-rich repeat and KH domain are drastically different structures. So similar motifs come from them are analogs.\n", "source_file": "d1ogqa_d1fjgc1.manual.ali"}
d1ogsa2d1dq3a4:d1ogsa2-d1dq3a4
d1ogsa2d1dq3a4
malisam
d1ogsa2d1dq3a4:d1ogsa2
d1ogsa2d1dq3a4:d1dq3a4
ARPCIPKSFGYSSVVCVCNASPPAQNLLLKSYFSEEGIGYSPIIVDITKDTFYKQP
IPPQILKEGKNAVLSFIAGLFDAEGHVSNKPGIELGMVNKRLIEDVTHYLNALGIKARIREKLRKDGIDYVLHVEEYSSLLRFYELIGKNLQNEEKREKLEKVLSNHKG
[ [ 4, 25 ], [ 5, 26 ], [ 6, 27 ], [ 7, 28 ], [ 8, 29 ], [ 13, 30 ], [ 14, 31 ], [ 15, 32 ], [ 16, 33 ], [ 17, 34 ], [ 18, 35 ], [ 19, 36 ], [ 20, 39 ], [ 21, 40 ], [ 22, 41 ], [ 23, 42 ], [ 24, 43 ], [ 25, 44 ], [ 26, 45 ], [ 27, 46 ], [ 28, 47 ], [ 29, 48 ], [ 30, 49 ], [ 31, 50 ], [ 32, 51 ], [ 33, 52 ], [ 41, 55 ], [ 42, 56 ], [ 43, 57 ], [ 44, 58 ], [ 45, 59 ], [ 46, 60 ], [ 47, 61 ], [ 48, 68 ], [ 49, 69 ], [ 50, 70 ], [ 51, 71 ], [ 52, 72 ], [ 53, 73 ], [ 54, 74 ], [ 55, 75 ] ]
0
[]
{"notes": "The motif in 1ogs: first two strands come from N-terminal extension, helix belongs to TIM-barrel, last two strands are insertion to TIM-barrel.\nHybrid.\n", "source_file": "d1ogsa2d1dq3a4.manual.ali"}
d1ogsa2d1is1a_:d1ogsa2-d1is1a_
d1ogsa2d1is1a_
malisam
d1ogsa2d1is1a_:d1ogsa2
d1ogsa2d1is1a_:d1is1a_
ARPCIPKSFGYSSVVCVCNASPPAQNLLLKSYFSEEGIGYSPIIVDITKDTFYKQP
TGRAHPSLLSGISVEYYGAATPLNQVANVVAEDARTLAITVFDKELTQKVEKAIMMSDLGLNPMSAGTIIRVPLPPL
[ [ 4, 29 ], [ 5, 30 ], [ 6, 31 ], [ 13, 34 ], [ 14, 35 ], [ 15, 36 ], [ 16, 37 ], [ 17, 38 ], [ 18, 39 ], [ 19, 40 ], [ 20, 43 ], [ 21, 44 ], [ 22, 45 ], [ 23, 46 ], [ 24, 47 ], [ 25, 48 ], [ 26, 49 ], [ 27, 50 ], [ 28, 51 ], [ 29, 52 ], [ 30, 53 ], [ 31, 54 ], [ 32, 55 ], [ 33, 56 ], [ 41, 61 ], [ 42, 62 ], [ 43, 63 ], [ 44, 64 ], [ 45, 65 ], [ 46, 66 ], [ 49, 67 ], [ 50, 68 ], [ 51, 69 ], [ 52, 70 ], [ 53, 71 ], [ 54, 72 ], [ 55, 73 ] ]
5.405405
[]
{"notes": "The motif in 1ogs: first two strands come from N-terminal extension, helix belongs to TIM-barrel, last two strands are insertion to TIM-barrel. Hybrid.\n", "source_file": "d1ogsa2d1is1a_.manual.ali"}
d1oi2a_d1uw1a_:d1oi2a_-d1uw1a_
d1oi2a_d1uw1a_
malisam
d1oi2a_d1uw1a_:d1oi2a_
d1oi2a_d1uw1a_:d1uw1a_
DVLDEQLAGLAKAHPSLTLHQDPVYVTRADAPVAGKVALLSGGGSGHEPMHCGYIGQGMLSGACPGEI
DDKKTNWLKRIYRVRPCVKCKVAPRNWKVKNKHLRIYNMCKTCFNNSIDIGDDTYHGHDDWLMYADS
[ [ 0, 1 ], [ 1, 2 ], [ 2, 3 ], [ 3, 4 ], [ 4, 5 ], [ 5, 6 ], [ 6, 7 ], [ 7, 8 ], [ 8, 9 ], [ 9, 10 ], [ 10, 11 ], [ 11, 12 ], [ 12, 13 ], [ 13, 14 ], [ 14, 15 ], [ 15, 23 ], [ 16, 24 ], [ 17, 25 ], [ 18, 26 ], [ 19, 27 ], [ 20, 28 ], [ 21, 29 ], [ 22, 32 ], [ 23, 33 ], [ 24, 34 ], [ 25, 35 ], [ 26, 36 ], [ 27, 37 ], [ 28, 38 ], [ 60, 56 ], [ 61, 57 ], [ 62, 58 ], [ 63, 59 ], [ 64, 60 ], [ 65, 61 ] ]
8.571429
[]
{"notes": "1uw1 is an artificial protein and can be used as analog to natural proteins.\n", "source_file": "d1oi2a_d1uw1a_.manual.ali"}
d1okra_d1m98a1:d1okra_-d1m98a1
d1okra_d1m98a1
malisam
d1okra_d1m98a1:d1okra_
d1okra_d1m98a1:d1m98a1
KGGFNSLVLNFVEKEDLSQDEIEELRNILNKKKGGFNSLVLNFVEKEDLSQDEIEELRNILNK
AADVVPATIARFKQLSAEDQLALIWFAYLEMGKTITLSANANAILVTIQGIDPGQQITVLRNCVVDMGFD
[ [ 0, 0 ], [ 1, 1 ], [ 2, 2 ], [ 3, 3 ], [ 4, 4 ], [ 5, 5 ], [ 6, 6 ], [ 7, 7 ], [ 8, 8 ], [ 9, 9 ], [ 10, 10 ], [ 11, 11 ], [ 12, 12 ], [ 13, 13 ], [ 16, 14 ], [ 17, 15 ], [ 18, 16 ], [ 19, 17 ], [ 20, 18 ], [ 21, 19 ], [ 22, 20 ], [ 23, 21 ], [ 24, 22 ], [ 25, 23 ], [ 26, 24 ], [ 27, 25 ], [ 28, 26 ], [ 29, 27 ], [ 30, 28 ], [ 31, 29 ], [ 32, 36 ], [ 33, 37 ], [ 34, 38 ], [ 35, 39 ], [ 36, 40 ], [ 37, 41 ], [ 38, 42 ], [ 39, 43 ], [ 40, 44 ], [ 41, 45 ], [ 42, 46 ], [ 43, 47 ], [ 44, 48 ], [ 45, 49 ], [ 46, 50 ], [ 49, 51 ], [ 50, 52 ], [ 51, 53 ], [ 52, 54 ], [ 53, 55 ], [ 54, 56 ], [ 55, 57 ], [ 56, 58 ], [ 57, 59 ], [ 58, 60 ], [ 59, 61 ], [ 60, 62 ], [ 61, 63 ], [ 62, 64 ] ]
6.779661
[]
{"notes": "The motif is composed of two alpha-hairpins. In 1okr, the C-terminal extension has three helices and is probably a duplicated DNA/RNA-binding 3-helix bundle, only adapted to dimerization.\nThe motif uses two helices from each chain and is an interface motif. In 1m98, the motif covers two entire duplicates and thus is not an interface motif. \nSo the alpha-hairpins in 1okr and 1m98 are probably analogs.\n", "source_file": "d1okra_d1m98a1.manual.ali"}
d1okra_d1v9da_:d1okra_-d1v9da_
d1okra_d1v9da_
malisam
d1okra_d1v9da_:d1okra_
d1okra_d1v9da_:d1v9da_
VEESDIKYKTSKNFINKVYKGGFNSLVLNFVEKEDLVEESDIKYKTSKNFINKVYKGGFNSLVLNFVEKEDL
VKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKEEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFSSLL
[ [ 3, 7 ], [ 4, 8 ], [ 5, 9 ], [ 6, 10 ], [ 7, 11 ], [ 8, 12 ], [ 9, 13 ], [ 10, 14 ], [ 11, 15 ], [ 12, 16 ], [ 13, 17 ], [ 14, 18 ], [ 15, 19 ], [ 16, 20 ], [ 17, 21 ], [ 18, 22 ], [ 20, 23 ], [ 21, 24 ], [ 22, 25 ], [ 23, 26 ], [ 24, 27 ], [ 25, 28 ], [ 26, 29 ], [ 27, 30 ], [ 28, 31 ], [ 29, 32 ], [ 30, 33 ], [ 31, 34 ], [ 32, 35 ], [ 39, 41 ], [ 40, 42 ], [ 41, 43 ], [ 42, 44 ], [ 43, 45 ], [ 44, 46 ], [ 45, 47 ], [ 46, 48 ], [ 47, 49 ], [ 48, 50 ], [ 49, 51 ], [ 50, 52 ], [ 58, 54 ], [ 59, 55 ], [ 60, 56 ], [ 61, 57 ], [ 62, 58 ], [ 63, 59 ], [ 64, 60 ], [ 65, 61 ], [ 66, 62 ], [ 67, 63 ], [ 68, 64 ], [ 69, 65 ], [ 70, 66 ] ]
5.555556
[]
{"notes": "The motif in 1okr: comes from two monomers, interface motif.\n", "source_file": "d1okra_d1v9da_.manual.ali"}
d1omoa_d1i7b.1:d1omoa_-d1i7b.1
d1omoa_d1i7b.1
malisam
d1omoa_d1i7b.1:d1omoa_
d1omoa_d1i7b.1:d1i7b.1
GKAQMPPKVYLEFEKGDLRAMPAHLMGYAGLKWVNSHPGNPDKGKAQMPPKVYLEFEKGDLRAMPAHLMGYAGLKWVNSHPGNPDK
AHFFEGTEKLLEVWFSRQQPGFDSIQSFFYSRKNFMKNSDCWYLYTLDFPESQPDQTLEILMSELDKPGKFVTTLFVNQSNDYNFVFTSFAKK
[ [ 1, 3 ], [ 2, 4 ], [ 3, 5 ], [ 4, 6 ], [ 6, 7 ], [ 7, 8 ], [ 8, 9 ], [ 9, 10 ], [ 10, 11 ], [ 11, 12 ], [ 12, 13 ], [ 13, 14 ], [ 15, 26 ], [ 16, 27 ], [ 17, 28 ], [ 18, 29 ], [ 19, 30 ], [ 20, 31 ], [ 21, 32 ], [ 22, 33 ], [ 26, 37 ], [ 27, 38 ], [ 28, 39 ], [ 29, 40 ], [ 30, 41 ], [ 31, 42 ], [ 32, 43 ], [ 33, 44 ], [ 34, 45 ], [ 35, 46 ], [ 36, 47 ], [ 37, 48 ], [ 44, 52 ], [ 45, 53 ], [ 46, 54 ], [ 47, 55 ], [ 48, 56 ], [ 50, 57 ], [ 51, 58 ], [ 52, 59 ], [ 53, 60 ], [ 54, 61 ], [ 55, 62 ], [ 56, 63 ], [ 57, 68 ], [ 58, 69 ], [ 59, 70 ], [ 60, 71 ], [ 61, 72 ], [ 62, 73 ], [ 63, 74 ], [ 64, 75 ], [ 65, 76 ], [ 66, 77 ], [ 67, 78 ], [ 70, 81 ], [ 71, 82 ], [ 72, 83 ], [ 73, 84 ], [ 74, 85 ], [ 75, 86 ], [ 76, 87 ], [ 77, 88 ], [ 78, 89 ], [ 79, 90 ], [ 80, 91 ], [ 81, 92 ] ]
4.477612
[]
{"notes": "The motif in 1omo: interface motif uses elements from the two dimerization domains;\nThe motif in 1i7b: interface motif uses elements from the two duplicates;\nSince the dimerization domain in 1omo and the duplicate in 1i7b are so different and so unlikely to evolutionarily related, these two motifs are analogs.\n", "source_file": "d1omoa_d1i7b.1.manual.ali"}
d1ovma1d1914_2:d1ovma1-d1914_2
d1ovma1d1914_2
malisam
d1ovma1d1914_2:d1ovma1
d1ovma1d1914_2:d1914_2
HKQAHADSACLKAFRDAAENKLAMSKAQTIEVQPHAARVGDVWFTGIPMNQAIETLVELCKQHVHA
MVLLESEQFLTELTRLFQKCRSSGSVFITLKKYDEGLEPAENKCLLRATDGKRKISTVVSSKEVNKFQMAYSNLLRANMDGLKKR
[ [ 9, 4 ], [ 10, 5 ], [ 11, 6 ], [ 12, 7 ], [ 13, 8 ], [ 14, 9 ], [ 15, 10 ], [ 16, 11 ], [ 17, 12 ], [ 18, 13 ], [ 19, 14 ], [ 20, 15 ], [ 21, 16 ], [ 22, 17 ], [ 23, 18 ], [ 24, 19 ], [ 25, 20 ], [ 27, 25 ], [ 28, 26 ], [ 29, 27 ], [ 30, 28 ], [ 31, 29 ], [ 32, 30 ], [ 33, 31 ], [ 34, 43 ], [ 35, 44 ], [ 36, 45 ], [ 37, 46 ], [ 38, 47 ], [ 39, 48 ], [ 40, 53 ], [ 41, 54 ], [ 42, 55 ], [ 43, 56 ], [ 44, 57 ], [ 47, 62 ], [ 48, 63 ], [ 49, 64 ], [ 50, 65 ], [ 51, 66 ], [ 52, 67 ], [ 53, 68 ], [ 54, 69 ], [ 55, 70 ], [ 56, 71 ], [ 57, 72 ], [ 58, 73 ], [ 59, 74 ], [ 60, 75 ], [ 61, 76 ], [ 62, 77 ], [ 63, 78 ] ]
9.615385
[]
{"notes": "The motif in 1ovm: compared with d1dhs__ (same superfamily, same cofactor-binding mode), a helix-to-strand transition generated the motif. \nThe motif in 1914: core motif, comparing the two homologous domains (SRP9 and SRP14).\nStrictly speaking, the motif in 1ovm is not a hybrid motif. However, since 1ovm is a Rossmann-like structure while 1914 is apparently not, these two\nmotifs are analogs.\n", "source_file": "d1ovma1d1914_2.manual.ali"}
d1p5gx1d1xppa_:d1p5gx1-d1xppa_
d1p5gx1d1xppa_
malisam
d1p5gx1d1xppa_:d1p5gx1
d1p5gx1d1xppa_:d1xppa_
LPASIFRAYDIRGVVGDTLTAETAYWIGRAIGSESLARGEGKSGVMLTGSHNPPDYNGFKIVVAGETLANEQIQALRERIEKND
AESSLRVISKEKNSITVEMINYDNTLLRTLVEEILKDDQVDEARYYIKHPVIDNPQIYVRVKSGKPQSAIKRAVRKLSKLYEDLGTQFQKEFQRYESDH
[ [ 4, 5 ], [ 5, 6 ], [ 6, 8 ], [ 7, 9 ], [ 8, 14 ], [ 9, 15 ], [ 10, 16 ], [ 11, 17 ], [ 12, 18 ], [ 13, 19 ], [ 14, 20 ], [ 18, 21 ], [ 19, 22 ], [ 20, 23 ], [ 21, 24 ], [ 22, 25 ], [ 23, 26 ], [ 24, 27 ], [ 25, 28 ], [ 26, 29 ], [ 27, 30 ], [ 28, 31 ], [ 29, 32 ], [ 30, 33 ], [ 31, 34 ], [ 32, 35 ], [ 33, 36 ], [ 34, 37 ], [ 42, 40 ], [ 43, 41 ], [ 44, 42 ], [ 45, 43 ], [ 46, 44 ], [ 47, 45 ], [ 48, 46 ], [ 54, 52 ], [ 55, 53 ], [ 56, 54 ], [ 57, 55 ], [ 58, 56 ], [ 59, 57 ], [ 60, 58 ], [ 61, 59 ], [ 62, 60 ], [ 63, 61 ], [ 64, 62 ], [ 65, 63 ], [ 66, 64 ], [ 68, 65 ], [ 69, 66 ], [ 70, 67 ], [ 71, 68 ], [ 72, 69 ], [ 73, 70 ], [ 74, 71 ], [ 75, 72 ], [ 76, 73 ], [ 77, 74 ], [ 78, 75 ], [ 79, 76 ], [ 80, 77 ], [ 81, 78 ], [ 82, 79 ] ]
7.936508
[]
{"notes": "The motif in 1p5g: comparing the three duplicates, the first two strands are insertion. Hybrid motif. Since the three domains apparently have a\nmini-Rossman core, this motif can be used as analog to a+b motifs.\n", "source_file": "d1p5gx1d1xppa_.manual.ali"}
d1pdz_1d1b66a_:d1pdz_1-d1b66a_
d1pdz_1d1b66a_
malisam
d1pdz_1d1b66a_:d1pdz_1
d1pdz_1d1b66a_:d1b66a_
PVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMRMGTEVYHHLKAVIKARFGLDATAVGDEGGFAPNILNNKDALDLIQEAIKKAGYTGKIEIGMDVAASEF
LRRRARLSRLVSFSASHRLHSPSLSAEENLKVFGKCNNPNGHGHNYKVVVTIHGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADVVSTTENVAVYIWENLQRLLPVGALYKVKVYETDNNIVVYKGE
[ [ 0, 4 ], [ 1, 5 ], [ 2, 6 ], [ 3, 7 ], [ 4, 8 ], [ 5, 9 ], [ 6, 10 ], [ 8, 11 ], [ 9, 12 ], [ 10, 13 ], [ 17, 43 ], [ 18, 44 ], [ 19, 45 ], [ 21, 46 ], [ 22, 47 ], [ 23, 48 ], [ 24, 49 ], [ 25, 50 ], [ 26, 51 ], [ 38, 64 ], [ 39, 65 ], [ 40, 66 ], [ 41, 67 ], [ 42, 68 ], [ 43, 69 ], [ 44, 70 ], [ 45, 71 ], [ 46, 72 ], [ 47, 73 ], [ 48, 74 ], [ 49, 75 ], [ 50, 76 ], [ 51, 78 ], [ 52, 79 ], [ 53, 80 ], [ 54, 81 ], [ 55, 82 ], [ 72, 97 ], [ 73, 98 ], [ 74, 99 ], [ 75, 100 ], [ 76, 101 ], [ 77, 102 ], [ 78, 103 ], [ 79, 104 ], [ 80, 105 ], [ 81, 106 ], [ 82, 107 ], [ 83, 108 ], [ 84, 109 ], [ 85, 110 ], [ 86, 111 ], [ 87, 112 ], [ 88, 113 ], [ 89, 114 ], [ 90, 115 ], [ 91, 116 ], [ 92, 117 ], [ 93, 118 ], [ 94, 119 ], [ 95, 121 ], [ 96, 122 ], [ 97, 123 ], [ 98, 124 ], [ 99, 125 ], [ 100, 126 ], [ 101, 127 ] ]
10.447761
[]
{"notes": "Compare 1pdz to d1bqg_1 (other family), the anti-parallel strand is the insertion. The motif in 1pdz comes from a TIM-barrel-like structure.\nThe motif in 1b66 comes from a a+b sandwich. They are analogs.\n", "source_file": "d1pdz_1d1b66a_.manual.ali"}
d1pdz_1d1irum_:d1pdz_1-d1irum_
d1pdz_1d1irum_
malisam
d1pdz_1d1irum_:d1pdz_1
d1pdz_1d1irum_:d1irum_
PVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMRMGTEVYHHLKAVIKARFGLDATAVGDEGGFAPNILNNKDALDLIQEAIKKAGYTGKIEIGMDVAASEF
FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEE
[ [ 0, 5 ], [ 1, 6 ], [ 2, 7 ], [ 3, 8 ], [ 4, 9 ], [ 5, 10 ], [ 6, 11 ], [ 18, 16 ], [ 19, 17 ], [ 21, 18 ], [ 22, 19 ], [ 23, 20 ], [ 24, 21 ], [ 25, 22 ], [ 26, 23 ], [ 35, 24 ], [ 36, 25 ], [ 37, 26 ], [ 38, 27 ], [ 39, 28 ], [ 40, 29 ], [ 41, 30 ], [ 42, 31 ], [ 43, 32 ], [ 44, 33 ], [ 45, 34 ], [ 46, 35 ], [ 47, 36 ], [ 48, 37 ], [ 49, 38 ], [ 50, 39 ], [ 51, 40 ], [ 52, 41 ], [ 53, 42 ], [ 54, 43 ], [ 55, 44 ], [ 72, 50 ], [ 73, 51 ], [ 74, 52 ], [ 75, 53 ], [ 76, 54 ], [ 77, 55 ], [ 78, 56 ], [ 79, 57 ], [ 80, 58 ], [ 81, 59 ], [ 82, 60 ], [ 83, 61 ], [ 84, 62 ], [ 85, 63 ], [ 86, 64 ], [ 87, 65 ], [ 88, 66 ], [ 89, 67 ], [ 93, 72 ], [ 94, 73 ], [ 95, 74 ], [ 96, 75 ], [ 97, 76 ], [ 98, 77 ], [ 99, 78 ], [ 100, 79 ] ]
3.225806
[]
{"notes": "Compare 1pdz to d1bqg_1 (other family), the anti-parallel strand is the insertion. The motif in 1pdz comes from a TIM-barrel-like structure.\nThe motif in 1iru_M comes from Ntn-like a+b sandwich. They are analogs.\n", "source_file": "d1pdz_1d1irum_.manual.ali"}
d1piea1d1nxha_:d1piea1-d1nxha_
d1piea1d1nxha_
malisam
d1piea1d1nxha_:d1piea1
d1piea1d1nxha_:d1nxha_
DGELWSNYVKGMIVMLKGAGYEIDPTASGLSSSASLELLVGVVLDDLFNLNVPRLELVQLGQKTENDYIGVNSG
REYSEALSEGRRRLHEILRSEGELMRLMKRRILESYRWQEDVVKPLSRELEIDVEEFQDILMDKLDMSSLEALHPRFESARPRCIREKLHSDLQLCWLVDVMEIISVDDAEALKDEITELVLAG
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8.77193
[]
{"notes": "The motif in 1pie: two helices come from the \"Ribosomal protein S5 domain 2-like\" core and the third helix comes from C-terminal\nextension. hybrid motif.\n", "source_file": "d1piea1d1nxha_.manual.ali"}
d1piea1d1q0qa1:d1piea1-d1q0qa1
d1piea1d1q0qa1
malisam
d1piea1d1q0qa1:d1piea1
d1piea1d1q0qa1:d1q0qa1
DGELWSNYVKGMIVMLKGAGYEIDPTASGLSSSASLELLVGVVLDDLFNLNVPRLELVQLGQKTENDYIGVNSG
EPQCVDDVLSVDANAREVARKEVMRLASKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMR
[ [ 3, 10 ], [ 4, 11 ], [ 5, 12 ], [ 6, 13 ], [ 7, 14 ], [ 8, 15 ], [ 9, 16 ], [ 10, 17 ], [ 11, 18 ], [ 12, 19 ], [ 13, 20 ], [ 14, 21 ], [ 15, 22 ], [ 16, 23 ], [ 17, 24 ], [ 18, 25 ], [ 19, 26 ], [ 30, 59 ], [ 31, 60 ], [ 32, 61 ], [ 33, 62 ], [ 34, 63 ], [ 35, 64 ], [ 36, 65 ], [ 37, 66 ], [ 38, 67 ], [ 39, 68 ], [ 40, 69 ], [ 41, 70 ], [ 42, 71 ], [ 43, 72 ], [ 44, 73 ], [ 45, 74 ], [ 46, 75 ], [ 47, 76 ], [ 51, 78 ], [ 52, 79 ], [ 53, 80 ], [ 54, 81 ], [ 55, 82 ], [ 56, 83 ], [ 57, 84 ], [ 58, 85 ], [ 59, 86 ], [ 60, 87 ], [ 61, 88 ], [ 62, 89 ], [ 63, 90 ], [ 64, 91 ], [ 65, 92 ], [ 66, 93 ], [ 67, 94 ], [ 68, 95 ] ]
5.660377
[]
{"notes": "The motif in 1pie: two helices come from the \"Ribosomal protein S5 domain 2-like\" core and the third helix comes from C-terminal\nextension. hybrid motif.\n", "source_file": "d1piea1d1q0qa1.manual.ali"}
d1pqsa_d1i7la2:d1pqsa_-d1i7la2
d1pqsa_d1i7la2
malisam
d1pqsa_d1i7la2:d1pqsa_
d1pqsa_d1i7la2:d1i7la2
SEIFTLLVEKVWNFDDLIMAINSKISNTHNNNISPITKIKYQDEDGDFVVLGSDEDWNVAKEMLAENNEKFLNIRLY
PLIEQTYYPNHREMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDAK
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9.803922
[]
{"notes": "1pqs is a cloning artefact. It should be a ubiquitin fold.\n", "source_file": "d1pqsa_d1i7la2.manual.ali"}
d1pqsa_d1poh__:d1pqsa_-d1poh__
d1pqsa_d1poh__
malisam
d1pqsa_d1poh__:d1pqsa_
d1pqsa_d1poh__:d1poh__
SEIFTLLVEKVWNFDDLIMAINSKISNTHNNNISPITKIKYQDEDGDFVVLGSDEDWNVAKEMLAENNEKFLNIRLY
MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKLMAELE
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7.272727
[]
{"notes": "1pqs is a cloning artefact. It should be a ubiquitin fold.\n", "source_file": "d1pqsa_d1poh__.manual.ali"}
End of preview. Expand in Data Studio

MALISAM (Hugging Face Port)

Benchmark for structural analogs—non-homologous protein motifs with similar 3D structures.

Overview

  • 130 structurally aligned domain pairs with no evolutionary relationship
  • First benchmark to explicitly evaluate analog discrimination
  • Alignments are manually curated based on structural similarity alone

Features

  • pair_id, group_id, set_name
  • seq1_id, seq2_id, seq1, seq2
  • ref_alignment: list of residue index pairs (0-based)
  • percent_identity: sequence identity across aligned residues
  • scop_labels: optional (typically empty for MALISAM)
  • meta: optional notes extracted from original text files

Usage

from datasets import load_dataset
ds = load_dataset("DeepFoldProtein/MALISAM", name="all", split="test")
ex = ds[0]
print(ex["pair_id"], ex["ref_alignment"][:5])

Citation

@article{Cheng2007MALISAM,
  title = {MALISAM: a database of structurally analogous motifs in proteins},
  volume = {36},
  ISSN = {1362-4962},
  url = {http://dx.doi.org/10.1093/nar/gkm698},
  DOI = {10.1093/nar/gkm698},
  number = {Database},
  journal = {Nucleic Acids Research},
  publisher = {Oxford University Press (OUP)},
  author = {Cheng, H. and Kim, B.-H. and Grishin, N. V.},
  year = {2007},
  month = dec,
  pages = {D211--D217}
}
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