armanc/pubmed-rct20k · Datasets at Hugging Face

abstract_id stringlengths 8 8	label stringclasses 5 values	text stringlengths 1 1.39k	sentence_id int64 0 30
25001475	methods	Primary outcome was @-day mortality .	4
25001475	methods	Secondary outcomes were intensive care unit ( ICU ) and @-day mortality , severity of circulatory shock assessed by mean arterial pressure , serum lactate , fluid balance and the extended Sequential Organ Failure assessment ( SOFA ) score .	5
25001475	results	There was no significance difference between targeted temperature management at @ C or @ C on @-day mortality -LSB- log-rank test , p = @ , hazard ratio @ , @ % confidence interval ( CI ) @-@ @ -RSB- or ICU mortality ( @ vs. @ % , p = @ ; relative risk @ , @ % CI @-@ @ ) .	6
25001475	results	Serum lactate and the extended cardiovascular SOFA score were higher in the TTM@ group ( p < @ ) .	7
25001475	conclusions	We found no benefit in survival or severity of circulatory shock with targeted temperature management at @ C as compared to @ C in patients with shock on admission after OHCA .	8
25406902	background	Youths with a family history of alcohol and other drug use disorders ( FH + ) are at a greater risk of developing substance use disorders than their peers with no such family histories ( FH - ) , and this increased risk may be related to impaired maturation of forebrain circuitry .	0
25406902	background	FH + individuals have shown altered forebrain activity at rest and while performing cognitive tasks .	1
25406902	background	However , it is not fully understood how forebrain activity is altered in FH + individuals , and ultimately how these alterations may contribute to substance use disorder risk .	2
25406902	methods	In this study , we tested @ FH + and @ FH - youths performing a go/no-go task and examined activations in blocks with only go trials ( Go Only ) , blocks with @ % go and @ % no-go trials ( Go/NoGo ) , and a contrast of those @ blocks .	3
25406902	results	FH + youths had significantly greater cerebral activations in both the Go and Go/NoGo blocks than FH - youths in regions including the posterior cingulate/precuneus , bilateral middle/superior temporal gyrus , and medial superior frontal gyrus with no significant group differences in the subtraction between Go Only and Go/NoGo blocks .	4
25406902	results	Additionally , FH + youths had moderately slower reaction times on go trials in the Go Only blocks .	5
25406902	conclusions	Our findings suggest that global activation increase in FH + youths are modulated by FH density and are not specific to the inhibitory components of the task .	6
25406902	conclusions	This pattern of increased activations in FH + youths may be at least partially due to impaired forebrain white matter development leading to greater activations/less efficient neural communication during task performance .	7
25471989	background	Risk factors have been proposed for running injuries including ( a ) reduced muscular strength , ( b ) excessive joint movements and ( c ) excessive joint moments in the frontal and transverse planes .	0
25471989	background	To date , many running injury prevention programs have focused on a `` top down '' approach to strengthen the hip musculature in the attempt to reduce movements and moments at the hip , knee , and/or ankle joints .	1
25471989	background	However , running mechanics did not change when hip muscle strength increased .	2
25471989	background	It could be speculated that emphasis should be placed on increasing the strength of the ankle joint for a `` ground up '' approach .	3
25471989	background	Strengthening of the large and small muscles crossing the ankle joint is assumed to change the force distribution for these muscles and to increase the use of smaller muscles .	4
25471989	background	This would be associated with a reduction of joint and insertion forces , which could have a beneficial effect on injury prevention .	5
25471989	background	However , training of the ankle joint as an injury prevention strategy has not been studied .	6
25471989	background	Ankle strengthening techniques include isolated strengthening or movement-related strengthening such as functional balance training .	7
25471989	background	There is little knowledge about the efficacy of such training programs on strength alteration , gait or injury reduction .	8
25471989	methods	Novice runners will be randomly assigned to one of three groups : an isolated ankle strengthening group ( strength , n = @ ) , a functional balance training group ( balance , n = @ ) or an activity-matched control group ( control , n = @ ) .	9
25471989	methods	Isokinetic strength will be measured using a Biodex System @ dynamometer .	10
25471989	methods	Running kinematics and kinetics will be assessed using @D motion analysis and a force platform .	11
25471989	methods	Postural control will be assessed by quantifying the magnitude and temporal structure of the center of pressure trace during single leg stance on a force platform .	12
25471989	methods	The change pre - and post-training in isokinetic strength , running mechanics , and postural control variables will be compared following the interventions .	13
25471989	methods	Injuries rates will be compared between groups over @months .	14
25471989	conclusions	Avoiding injury will allow individuals to enjoy the benefits of participating in aerobic activities and reduce the healthcare costs associated with running injuries .	15
24694205	background	Vitamin B@ deficiency causes neurologic and psychiatric disease , especially in older adults .	0
24694205	background	Subacute combined degeneration is characterized by damage to the posterior and lateral spinal cord affecting the corticospinal tract .	1
24694205	objective	To test corticospinal tract projections using motor evoked potentials ( MEPs ) by transcranial magnetic stimulation ( TMS ) in asymptomatic older adults with low vitamin B@ ( B@ ) levels .	2
24694205	methods	Cross-sectional study of @ healthy older adults ( > @ years ) .	3
24694205	methods	MEPs were recorded in the abductor pollicis brevis and tibialis anterior muscles , at rest and during slight tonic contraction .	4
24694205	methods	Central motor conduction time ( CMCT ) was derived from the latency of MEPs and peripheral motor conduction time ( PMCT ) .	5
24694205	methods	Neurophysiological variables were analyzed statistically according to B@ status .	6
24694205	results	Median age was @ years ( @ % women ) .	7
24694205	results	Twenty-six out of the @ subjects had low vitamin B@ levels ( B@ < @pmol/l ) .	8
24694205	results	MEPs were recorded for all subjects in upper and lower extremities .	9
24694205	results	There were no significant differences in either latency or amplitude of MEPs and CMCT between low and normal B@ groups .	10
24694205	results	There was a significant PMCT delay in the lower extremities in the low B@ group ( p = @ ) .	11
24694205	conclusions	No subclinical abnormality of the corticospinal tract is detected in asymptomatic B@-deficient older adults .	12
24694205	conclusions	The peripheral nervous system appears to be more vulnerable to damage attributable to this vitamin deficit .	13
24694205	conclusions	The neurophysiological evaluation of asymptomatic older adults with lower B@ levels should be focused mainly in peripheral nervous system evaluation .	14
24576512	background	Uncontrolled hypertension ( HTN ) is a significant public health problem among blacks in the United States .	0
24576512	background	Despite the proven efficacy of therapeutic lifestyle change ( TLC ) on blood pressure ( BP ) reduction in clinical trials , few studies have examined their effectiveness in church-based settings-an influential institution for health promotion in black communities .	1
24576512	methods	Using a cluster-randomized , @-arm trial design , this study evaluates the effectiveness of a faith-based TLC intervention vs health education ( HE ) control on BP reduction among hypertensive black adults .	2
24576512	methods	The intervention is delivered by trained lay health advisors through group TLC sessions plus motivational interviewing in @ black churches .	3
24576512	methods	Participants in the intervention group receive @ weekly TLC sessions targeting weight loss , increasing physical activity , fruit , vegetable and low-fat dairy intake , and decreasing fat and sodium intake , plus @ monthly individual motivational interviewing sessions .	4
24576512	methods	Participants in the control group attend @ weekly classes on HTN and other health topics delivered by health care experts .	5
24576512	methods	The primary outcome is change in BP from baseline to @ months .	6
24576512	methods	Secondary outcomes include level of physical activity , percent change in weight , and fruit and vegetable consumption at @ months , and BP control at @ months .	7
24576512	conclusions	If successful , this trial will provide an alternative and culturally appropriate model for HTN control through evidence-based lifestyle modification delivered in churches by lay health advisors .	8
24807407	background	The classification of clinical severity of Ebstein anomaly still remains a challenge .	0
24807407	background	The aim of this study was to focus on the interaction of the pathologically altered right heart with the anatomically-supposedly-normal left heart and to derive from cardiac magnetic resonance ( CMR ) a simple imaging measure for the clinical severity of Ebstein anomaly .	1
24807407	results	Twenty-five patients at a mean age of @ years with unrepaired Ebstein anomaly were examined in a prospective study .	2
24807407	results	Disease severity was classified using CMR volumes and functional measurements in comparison with heart failure markers from clinical data , ECG , laboratory and cardiopulmonary exercise testing , and echocardiography .	3
24807407	results	All examinations were completed within @ hours .	4
24807407	results	A total right/left-volume index was defined from end-diastolic volume measurements in CMR : total right/left-volume index = ( RA + aRV + fRV ) / ( LA+LV ) .	5
24807407	results	Mean total right/left-volume index was @ ( normal values : @ ) .	6
24807407	results	This new total right/left-volume index correlated with almost all clinically used biomarkers of heart failure : brain natriuretic peptide ( r = @ ; P = @ ) , QRS ( r = @ ; P = @ ) , peak oxygen consumption/kg ( r = -@ ; P = @ ) , ventilatory response to carbon dioxide production at anaerobic threshold ( r = @ ; P = @ ) , the severity of tricuspid regurgitation ( r = @ ; P = @ ) , tricuspid valve offset ( r = @ ; P = @ ) , and tricuspid annular plane systolic excursion ( r = @ ; P = @ ) .	7
24807407	results	Previously described severity indices ( -LSB- RA + aRV -RSB- / -LSB- fRV + LA+LV -RSB- ) and fRV/LV end-diastolic volume corresponded only to some parameters .	8
24807407	conclusions	In patients with Ebstein anomaly , the easily acquired index of right-sided to left-sided heart volumes from CMR correlated well with established heart failure markers .	9
24807407	conclusions	Our data suggest that the total right/left-volume index should be used as a new and simplified CMR measure , allowing more accurate assessment of disease severity than previously described scoring systems .	10
24947717	objective	This study sought to investigate the association of beta-blocker therapy at discharge with clinical outcomes in patients with ST-segment elevation myocardial infarction ( STEMI ) after primary percutaneous coronary intervention ( PCI ) .	0
24947717	background	Limited data are available on the efficacy of beta-blocker therapy for secondary prevention in STEMI patients .	1
24947717	methods	Between November @ , @ and September @ , @ , @,@ patients were enrolled in nationwide , prospective , multicenter registries .	2
24947717	methods	Among these , we studied STEMI patients undergoing primary PCI who were discharged alive ( n = @,@ ) .	3
24947717	methods	We classified patients into the beta-blocker group ( n = @,@ ) and no-beta-blocker group ( n = @,@ ) according to the use of beta-blockers at discharge .	4
24947717	methods	Propensity-score matching analysis was also performed in @,@ patient triplets .	5
24947717	methods	The primary outcome was all-cause death .	6
24947717	results	The median follow-up duration was @ days ( interquartile range : @ to @ days ) .	7
24947717	results	All-cause death occurred in @ patients ( @ % ) of the beta-blocker group versus @ patients ( @ % ) of the no-beta-blocker group ( p < @ ) .	8
24947717	results	After @:@ propensity-score matching , beta-blocker therapy was associated with a lower incidence of all-cause death ( @ % vs. @ % , adjusted hazard ratio : @ , @ % confidence interval : @ to @ , p = @ ) .	9
24947717	results	The association with better outcome of beta-blocker therapy in terms of all-cause death was consistent across various subgroups , including patients with relatively low-risk profiles such as ejection fraction > @ % or single-vessel disease .	10
24947717	conclusions	Beta-blocker therapy at discharge was associated with improved survival in STEMI patients treated with primary PCI .	11
24947717	conclusions	Our results support the current American College of Cardiology/American Heart Association guidelines , which recommend long-term beta-blocker therapy in all patients with STEMI regardless of reperfusion therapy or risk profile .	12
24281275	objective	Local anesthetic wound infiltration is widely used as an effective adjunct during multimodal postoperative pain management .	0
24281275	objective	The aim of this study was to evaluate the effectiveness of continuous wound infusion of ropivacaine in postoperative pain relief , opioid sparing , incidence of nausea and vomiting , and bowel and liver function improvement in patients undergoing open hepatectomy .	1
24281275	methods	Forty patients undergoing open hepatectomy were enrolled in this prospective , randomized , double-blinded , placebo-controlled trial .	2
24281275	methods	Patients were divided into @ groups : the @ % saline continuous infusion group ( the control group ; n = @ ) and the ropivacaine continuous infusion group ( the Ropi group ; n = @ ) .	3
24281275	methods	Outcomes measured postoperatively were pain score at rest and on movement , sufentanil consumption , incidence of nausea and vomiting , and sedation score across @ postoperative hours .	4
24281275	methods	Time to bowel recovery , liver function change , mean length of hospitalization , patient satisfaction , and other data after @ postoperative hours were collected until hospital discharge .	5
24281275	results	Pain scores at rest were lower for the ropivacaine group and reached significance after @ and @ hours ( P < @ ) .	6
24281275	results	Sufentanil consumption ( @ vs. @ g ; P < @ ) after @ hours , time to bowel recovery ( @ vs. @ d ; P < @ ) , incidence of nausea and vomiting ( @ vs. @ ; P < @ ) , and mean length of hospitalization ( @ vs. @ d ; P < @ ) were significantly reduced , and the sedation score and liver function change were also comparable between the @ groups .	7
24281275	results	There was no difference with respect to pain scores on movement , nor with respect to patient satisfaction .	8
24281275	conclusions	Surgical wound infusion with ropivacaine after hepatectomy can improve pain relief at rest and accelerate recovery and discharge .	9
24911353	objective	Tuberculosis ( TB ) is highly prevalent among HIV-infected people , including those receiving combination antiretroviral therapy ( cART ) , necessitating a well tolerated and efficacious TB vaccine for these populations .	0
24911353	objective	We evaluated the safety and immunogenicity of the candidate TB vaccine M@/AS@ in adults with well controlled HIV infection on cART .	1
24911353	methods	A randomized , observer-blind , controlled trial ( NCT@ ) .	2
24911353	methods	HIV-infected adults on cART in Switzerland were randomized @:@:@ to receive two doses , @ month apart , of M@/AS@ , AS@ or @ % physiological saline ( N = @ , N = @ and N = @ , respectively ) and were followed up to @ months postdose @ ( D@ ) .	3
24911353	methods	Individuals with CD@ cell counts below @ cells/l were excluded .	4
24911353	methods	Adverse events ( AEs ) including HIV-specific and laboratory safety parameters were recorded .	5
24911353	methods	Cell-mediated ( ICS ) and humoral ( ELISA ) responses were evaluated before vaccination , @ month after each dose ( D@ , D@ ) and D@ .	6
24911353	results	Thirty-seven individuals -LSB- interquartile range ( IQR ) CD@ cell counts at screening : @-@ cells/l ; undetectable HIV-@ viremia -RSB- were enrolled ; @ % of individuals reported previous BCG vaccination , @ % tested negative for the QuantiFERON-TB assay .	7
24911353	results	For M@/AS@ recipients , no vaccine-related serious AEs or cART-regimen adjustments were recorded , and there were no clinically relevant effects on laboratory safety parameters , HIV-@ viral loads or CD@ cell counts .	8
24911353	results	M@/AS@ was immunogenic , inducing persistent and polyfunctional M@-specific CD@ T-cell responses -LSB- medians @ % ( IQR @-@ @ ) at D@ -RSB- and @ % ( @-@ @ ) at D@ , predominantly CD@LIL-@TNF - , CD@LIL-@ and CD@LIL-@TNF-IFN - -RSB- .	9
24911353	results	All M@/AS@ vaccines were seropositive for anti-M@ IgG after second vaccination until study end .	10
24911353	conclusions	M@/AS@ was clinically well tolerated and immunogenic in this population , supporting further clinical evaluation in HIV-infected individuals in TB-endemic settings .	11
25318787	objective	The aim of this study was to investigate whether remedial hydration ( RH ) reduces the incidence of contrast-induced nephropathy ( CIN ) and short-term adverse events in ST-elevation myocardial infarction ( STEMI ) patients undergoing primary percutaneous coronary intervention ( PCI ) .	0

25001475

methods

Primary outcome was @-day mortality .

4

25001475

methods

Secondary outcomes were intensive care unit ( ICU ) and @-day mortality , severity of circulatory shock assessed by mean arterial pressure , serum lactate , fluid balance and the extended Sequential Organ Failure assessment ( SOFA ) score .

5

25001475

results

There was no significance difference between targeted temperature management at @ C or @ C on @-day mortality -LSB- log-rank test , p = @ , hazard ratio @ , @ % confidence interval ( CI ) @-@ @ -RSB- or ICU mortality ( @ vs. @ % , p = @ ; relative risk @ , @ % CI @-@ @ ) .

6

25001475

results

Serum lactate and the extended cardiovascular SOFA score were higher in the TTM@ group ( p < @ ) .

7

25001475

conclusions

We found no benefit in survival or severity of circulatory shock with targeted temperature management at @ C as compared to @ C in patients with shock on admission after OHCA .

8

25406902

background

Youths with a family history of alcohol and other drug use disorders ( FH + ) are at a greater risk of developing substance use disorders than their peers with no such family histories ( FH - ) , and this increased risk may be related to impaired maturation of forebrain circuitry .

0

25406902

background

FH + individuals have shown altered forebrain activity at rest and while performing cognitive tasks .

1

25406902

background

However , it is not fully understood how forebrain activity is altered in FH + individuals , and ultimately how these alterations may contribute to substance use disorder risk .

2

25406902

methods

In this study , we tested @ FH + and @ FH - youths performing a go/no-go task and examined activations in blocks with only go trials ( Go Only ) , blocks with @ % go and @ % no-go trials ( Go/NoGo ) , and a contrast of those @ blocks .

3

25406902

results

FH + youths had significantly greater cerebral activations in both the Go and Go/NoGo blocks than FH - youths in regions including the posterior cingulate/precuneus , bilateral middle/superior temporal gyrus , and medial superior frontal gyrus with no significant group differences in the subtraction between Go Only and Go/NoGo blocks .

4

25406902

results

Additionally , FH + youths had moderately slower reaction times on go trials in the Go Only blocks .

5

25406902

conclusions

Our findings suggest that global activation increase in FH + youths are modulated by FH density and are not specific to the inhibitory components of the task .

6

25406902

conclusions

This pattern of increased activations in FH + youths may be at least partially due to impaired forebrain white matter development leading to greater activations/less efficient neural communication during task performance .

7

25471989

background

Risk factors have been proposed for running injuries including ( a ) reduced muscular strength , ( b ) excessive joint movements and ( c ) excessive joint moments in the frontal and transverse planes .

0

25471989

background

To date , many running injury prevention programs have focused on a `` top down '' approach to strengthen the hip musculature in the attempt to reduce movements and moments at the hip , knee , and/or ankle joints .

1

25471989

background

However , running mechanics did not change when hip muscle strength increased .

2

25471989

background

It could be speculated that emphasis should be placed on increasing the strength of the ankle joint for a `` ground up '' approach .

3

25471989

background

Strengthening of the large and small muscles crossing the ankle joint is assumed to change the force distribution for these muscles and to increase the use of smaller muscles .

4

25471989

background

This would be associated with a reduction of joint and insertion forces , which could have a beneficial effect on injury prevention .

5

25471989

background

However , training of the ankle joint as an injury prevention strategy has not been studied .

6

25471989

background

Ankle strengthening techniques include isolated strengthening or movement-related strengthening such as functional balance training .

7

25471989

background

There is little knowledge about the efficacy of such training programs on strength alteration , gait or injury reduction .

8

25471989

methods

Novice runners will be randomly assigned to one of three groups : an isolated ankle strengthening group ( strength , n = @ ) , a functional balance training group ( balance , n = @ ) or an activity-matched control group ( control , n = @ ) .

9

25471989

methods

Isokinetic strength will be measured using a Biodex System @ dynamometer .

10

25471989

methods

Running kinematics and kinetics will be assessed using @D motion analysis and a force platform .

11

25471989

methods

Postural control will be assessed by quantifying the magnitude and temporal structure of the center of pressure trace during single leg stance on a force platform .

12

25471989

methods

The change pre - and post-training in isokinetic strength , running mechanics , and postural control variables will be compared following the interventions .

13

25471989

methods

Injuries rates will be compared between groups over @months .

14

25471989

conclusions

Avoiding injury will allow individuals to enjoy the benefits of participating in aerobic activities and reduce the healthcare costs associated with running injuries .

15

24694205

background

Vitamin B@ deficiency causes neurologic and psychiatric disease , especially in older adults .

0

24694205

background

Subacute combined degeneration is characterized by damage to the posterior and lateral spinal cord affecting the corticospinal tract .

1

24694205

objective

To test corticospinal tract projections using motor evoked potentials ( MEPs ) by transcranial magnetic stimulation ( TMS ) in asymptomatic older adults with low vitamin B@ ( B@ ) levels .

2

24694205

methods

Cross-sectional study of @ healthy older adults ( > @ years ) .

3

24694205

methods

MEPs were recorded in the abductor pollicis brevis and tibialis anterior muscles , at rest and during slight tonic contraction .

4

24694205

methods

Central motor conduction time ( CMCT ) was derived from the latency of MEPs and peripheral motor conduction time ( PMCT ) .

5

24694205

methods

Neurophysiological variables were analyzed statistically according to B@ status .

6

24694205

results

Median age was @ years ( @ % women ) .

7

24694205

results

Twenty-six out of the @ subjects had low vitamin B@ levels ( B@ < @pmol/l ) .

8

24694205

results

MEPs were recorded for all subjects in upper and lower extremities .

9

24694205

results

There were no significant differences in either latency or amplitude of MEPs and CMCT between low and normal B@ groups .

10

24694205

results

There was a significant PMCT delay in the lower extremities in the low B@ group ( p = @ ) .

11

24694205

conclusions

No subclinical abnormality of the corticospinal tract is detected in asymptomatic B@-deficient older adults .

12

24694205

conclusions

The peripheral nervous system appears to be more vulnerable to damage attributable to this vitamin deficit .

13

24694205

conclusions

The neurophysiological evaluation of asymptomatic older adults with lower B@ levels should be focused mainly in peripheral nervous system evaluation .

14

24576512

background

Uncontrolled hypertension ( HTN ) is a significant public health problem among blacks in the United States .

0

24576512

background

Despite the proven efficacy of therapeutic lifestyle change ( TLC ) on blood pressure ( BP ) reduction in clinical trials , few studies have examined their effectiveness in church-based settings-an influential institution for health promotion in black communities .

1

24576512

methods

Using a cluster-randomized , @-arm trial design , this study evaluates the effectiveness of a faith-based TLC intervention vs health education ( HE ) control on BP reduction among hypertensive black adults .

2

24576512

methods

The intervention is delivered by trained lay health advisors through group TLC sessions plus motivational interviewing in @ black churches .

3

24576512

methods

Participants in the intervention group receive @ weekly TLC sessions targeting weight loss , increasing physical activity , fruit , vegetable and low-fat dairy intake , and decreasing fat and sodium intake , plus @ monthly individual motivational interviewing sessions .

4

24576512

methods

Participants in the control group attend @ weekly classes on HTN and other health topics delivered by health care experts .

5

24576512

methods

The primary outcome is change in BP from baseline to @ months .

6

24576512

methods

Secondary outcomes include level of physical activity , percent change in weight , and fruit and vegetable consumption at @ months , and BP control at @ months .

7

24576512

conclusions

If successful , this trial will provide an alternative and culturally appropriate model for HTN control through evidence-based lifestyle modification delivered in churches by lay health advisors .

8

24807407

background

The classification of clinical severity of Ebstein anomaly still remains a challenge .

0

24807407

background

The aim of this study was to focus on the interaction of the pathologically altered right heart with the anatomically-supposedly-normal left heart and to derive from cardiac magnetic resonance ( CMR ) a simple imaging measure for the clinical severity of Ebstein anomaly .

1

24807407

results

Twenty-five patients at a mean age of @ years with unrepaired Ebstein anomaly were examined in a prospective study .

2

24807407

results

Disease severity was classified using CMR volumes and functional measurements in comparison with heart failure markers from clinical data , ECG , laboratory and cardiopulmonary exercise testing , and echocardiography .

3

24807407

results

All examinations were completed within @ hours .

4

24807407

results

A total right/left-volume index was defined from end-diastolic volume measurements in CMR : total right/left-volume index = ( RA + aRV + fRV ) / ( LA+LV ) .

5

24807407

results

Mean total right/left-volume index was @ ( normal values : @ ) .

6

24807407

results

This new total right/left-volume index correlated with almost all clinically used biomarkers of heart failure : brain natriuretic peptide ( r = @ ; P = @ ) , QRS ( r = @ ; P = @ ) , peak oxygen consumption/kg ( r = -@ ; P = @ ) , ventilatory response to carbon dioxide production at anaerobic threshold ( r = @ ; P = @ ) , the severity of tricuspid regurgitation ( r = @ ; P = @ ) , tricuspid valve offset ( r = @ ; P = @ ) , and tricuspid annular plane systolic excursion ( r = @ ; P = @ ) .

7

24807407

results

Previously described severity indices ( -LSB- RA + aRV -RSB- / -LSB- fRV + LA+LV -RSB- ) and fRV/LV end-diastolic volume corresponded only to some parameters .

8

24807407

conclusions

In patients with Ebstein anomaly , the easily acquired index of right-sided to left-sided heart volumes from CMR correlated well with established heart failure markers .

9

24807407

conclusions

Our data suggest that the total right/left-volume index should be used as a new and simplified CMR measure , allowing more accurate assessment of disease severity than previously described scoring systems .

10

24947717

objective

This study sought to investigate the association of beta-blocker therapy at discharge with clinical outcomes in patients with ST-segment elevation myocardial infarction ( STEMI ) after primary percutaneous coronary intervention ( PCI ) .

0

24947717

background

Limited data are available on the efficacy of beta-blocker therapy for secondary prevention in STEMI patients .

1

24947717

methods

Between November @ , @ and September @ , @ , @,@ patients were enrolled in nationwide , prospective , multicenter registries .

2

24947717

methods

Among these , we studied STEMI patients undergoing primary PCI who were discharged alive ( n = @,@ ) .

3

24947717

methods

We classified patients into the beta-blocker group ( n = @,@ ) and no-beta-blocker group ( n = @,@ ) according to the use of beta-blockers at discharge .

4

24947717

methods

Propensity-score matching analysis was also performed in @,@ patient triplets .

5

24947717

methods

The primary outcome was all-cause death .

6

24947717

results

The median follow-up duration was @ days ( interquartile range : @ to @ days ) .

7

24947717

results

All-cause death occurred in @ patients ( @ % ) of the beta-blocker group versus @ patients ( @ % ) of the no-beta-blocker group ( p < @ ) .

8

24947717

results

After @:@ propensity-score matching , beta-blocker therapy was associated with a lower incidence of all-cause death ( @ % vs. @ % , adjusted hazard ratio : @ , @ % confidence interval : @ to @ , p = @ ) .

9

24947717

results

The association with better outcome of beta-blocker therapy in terms of all-cause death was consistent across various subgroups , including patients with relatively low-risk profiles such as ejection fraction > @ % or single-vessel disease .

10

24947717

conclusions

Beta-blocker therapy at discharge was associated with improved survival in STEMI patients treated with primary PCI .

11

24947717

conclusions

Our results support the current American College of Cardiology/American Heart Association guidelines , which recommend long-term beta-blocker therapy in all patients with STEMI regardless of reperfusion therapy or risk profile .

12

24281275

objective

Local anesthetic wound infiltration is widely used as an effective adjunct during multimodal postoperative pain management .

0

24281275

objective

The aim of this study was to evaluate the effectiveness of continuous wound infusion of ropivacaine in postoperative pain relief , opioid sparing , incidence of nausea and vomiting , and bowel and liver function improvement in patients undergoing open hepatectomy .

1

24281275

methods

Forty patients undergoing open hepatectomy were enrolled in this prospective , randomized , double-blinded , placebo-controlled trial .

2

24281275

methods

Patients were divided into @ groups : the @ % saline continuous infusion group ( the control group ; n = @ ) and the ropivacaine continuous infusion group ( the Ropi group ; n = @ ) .

3

24281275

methods

Outcomes measured postoperatively were pain score at rest and on movement , sufentanil consumption , incidence of nausea and vomiting , and sedation score across @ postoperative hours .

4

24281275

methods

Time to bowel recovery , liver function change , mean length of hospitalization , patient satisfaction , and other data after @ postoperative hours were collected until hospital discharge .

5

24281275

results

Pain scores at rest were lower for the ropivacaine group and reached significance after @ and @ hours ( P < @ ) .

6

24281275

results

Sufentanil consumption ( @ vs. @ g ; P < @ ) after @ hours , time to bowel recovery ( @ vs. @ d ; P < @ ) , incidence of nausea and vomiting ( @ vs. @ ; P < @ ) , and mean length of hospitalization ( @ vs. @ d ; P < @ ) were significantly reduced , and the sedation score and liver function change were also comparable between the @ groups .

7

24281275

results

There was no difference with respect to pain scores on movement , nor with respect to patient satisfaction .

8

24281275

conclusions

Surgical wound infusion with ropivacaine after hepatectomy can improve pain relief at rest and accelerate recovery and discharge .

9

24911353

objective

Tuberculosis ( TB ) is highly prevalent among HIV-infected people , including those receiving combination antiretroviral therapy ( cART ) , necessitating a well tolerated and efficacious TB vaccine for these populations .

0

24911353

objective

We evaluated the safety and immunogenicity of the candidate TB vaccine M@/AS@ in adults with well controlled HIV infection on cART .

1

24911353

methods

A randomized , observer-blind , controlled trial ( NCT@ ) .

2

24911353

methods

HIV-infected adults on cART in Switzerland were randomized @:@:@ to receive two doses , @ month apart , of M@/AS@ , AS@ or @ % physiological saline ( N = @ , N = @ and N = @ , respectively ) and were followed up to @ months postdose @ ( D@ ) .

3

24911353

methods

Individuals with CD@ cell counts below @ cells/l were excluded .

4

24911353

methods

Adverse events ( AEs ) including HIV-specific and laboratory safety parameters were recorded .

5

24911353

methods

Cell-mediated ( ICS ) and humoral ( ELISA ) responses were evaluated before vaccination , @ month after each dose ( D@ , D@ ) and D@ .

6

24911353

results

Thirty-seven individuals -LSB- interquartile range ( IQR ) CD@ cell counts at screening : @-@ cells/l ; undetectable HIV-@ viremia -RSB- were enrolled ; @ % of individuals reported previous BCG vaccination , @ % tested negative for the QuantiFERON-TB assay .

7

24911353

results

For M@/AS@ recipients , no vaccine-related serious AEs or cART-regimen adjustments were recorded , and there were no clinically relevant effects on laboratory safety parameters , HIV-@ viral loads or CD@ cell counts .

8

24911353

results

M@/AS@ was immunogenic , inducing persistent and polyfunctional M@-specific CD@ T-cell responses -LSB- medians @ % ( IQR @-@ @ ) at D@ -RSB- and @ % ( @-@ @ ) at D@ , predominantly CD@LIL-@TNF - , CD@LIL-@ and CD@LIL-@TNF-IFN - -RSB- .

9

24911353

results

All M@/AS@ vaccines were seropositive for anti-M@ IgG after second vaccination until study end .

10

24911353

conclusions

M@/AS@ was clinically well tolerated and immunogenic in this population , supporting further clinical evaluation in HIV-infected individuals in TB-endemic settings .

11

25318787

objective

The aim of this study was to investigate whether remedial hydration ( RH ) reduces the incidence of contrast-induced nephropathy ( CIN ) and short-term adverse events in ST-elevation myocardial infarction ( STEMI ) patients undergoing primary percutaneous coronary intervention ( PCI ) .

0