language:
- en
tags:
- biology
- ESM
- language-model
- protein
- VEP
pretty_name: VESM scores
size_categories:
- 100M<n<1B
Proteome-wide VESM variant effect scores
This repository provides precomputed proteome-wide (UniProtKB, hg19, and hg38) variant-effect prediction scores using the latest VESM models developed in the paper "Compressing the collective knowledge of ESM into a single protein language model" by Tuan Dinh, Seon-Kyeong Jang, Noah Zaitlen and Vasilis Ntranos.
- Models: VESM_3B, VESM3, sequence-only VESM3, and VESM++ (available at https://huggingface.co/ntranoslab/vesm).
VESM_3B and VESM3 are individual protein language models based on ESM2 (3B) and ESM3. The sequence-only VESM3 is the version of VESM3 using only sequence as the input. VESM++ is the ensemble of VESM_3B and VESM3.
Please see the corresponding GitHub repo (https://github.com/ntranoslab/vesm) for more details.
License
The predictions of VESM_3B are distributed under the MIT License. The VESM3 and VESM++ models are built with ESM3-Open (EvolutionaryScale), which is available under a non-commercial license agreement.